CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030304
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FANCM protein 
Protein Synonyms/Alias
 Fanconi anemia group M protein 
Gene Name
 FANCM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
823QTHIKPTKIVSLKKKubiquitination[1]
1890SRMFRRTKSYDSLLTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2022 AA 
Protein Sequence
MSGRQRTLFQ TWGSSISRSS GTPGCSSGTE RPQSPGSSKA PLPAAAEAQL ESDDDVLLVA 60
AYEAERQLCL ENGGFCTSAG ALWIYPTNCP VRDYQLHISR AALFCNTLVC LPTGLGKTFI 120
AAVVMYNFYR WFPSGKVVFM APTKPLVTQQ IEACYQVMGI PQSHMAEMTG STQASTRKEI 180
WCSKRVLFLT PQVMVNDLSR GACPAAEIKC LVIDEAHKAL GNYAYCQAVQ QVITNLLIGQ 240
IELRSEDSPD ILTYSHERKV EKLIVPLGEE LAAIQKTYIQ ILESFARSLI QRNVLMRRDI 300
PNLTKYQIIL ARDQFRKNPS PNIVGIQQGI IEGEFAICIS LYHGYELLQQ MGMRSLYFFL 360
CGIMDGTKGM TRSKNELGRN EDFMKLYNHL ECMFARTRST SANGISAIQQ GDKNKKFVYS 420
HPKLKKLEEV VIEHFKSWNA ENTTEKKRDE TRVMIFSSFR DSVQEIAEML SQHQPIIRVM 480
TFVGHASGKS TKGFTQKEQL EVVKQFRDGG YNTLVSTCVG EEGLDIGEVD LIICFDSQKS 540
PIRLVQRMGR TGRKRQGRIV IILSEGREER IYNQSQSNKR SIYKAISSNR QVLHFYQRSP 600
RMVPDGINPK LHKMFITHGV YEPEKPSRNL QRKSSIFSYR DGMRQSSLKK DWFLSEEEFK 660
LWNRLYRLRD SDEIKEITLP QVQFSSLQNE ENKPAQESTT GIHQLSLSEW RLWQDHPLPT 720
HQVDHSDRCR HFIGLMQMIE GMRHEEGECS YELEVESYLQ MEDVTSTFIA PRNESNNLAS 780
DTFITHKKSS FIKNINQGSS SSVIESDEEC AEIVKQTHIK PTKIVSLKKK VSKEIKKDQL 840
KKENNHGIID SVDNDRNSTV ENIFQEDLPN DKRTSDTDEI AATCTINENV IKEPCVLLTE 900
CQFTNKSTSS LAGNVLDSGY NSFNDEKSVS SNLFLPFEEE LYIVRTDDQF YNCHSLTKEV 960
LANVERFLSY SPPPLSGLSD LEYEIAKGTA LENLLFLPCA EHLRSDKCTC LLSHSAVNSQ 1020
QNLELNSLKC INYPSEKSCL YDIPNDNISD EPSLCDCDVH KHNQNENLVP NNRVQIHRSP 1080
AQNLVGENNH DVDNSDLPVL STDQDESLLL FEDVNTEFDD VSLSPLNSKS ESLPVSDKTA 1140
ISETPLVSQF LISDELLLDN NSELQDQITR DANSFKSRDQ RGVQEEKVKN HEDIFDCSRD 1200
LFSVTFDLGF CSPDSDDEIL EHTSDSNRPL DDLYGRYLEI KEISDANYVS NQALIPRDHS 1260
KNFTSGTVII PSNEDMQNPN YVHLPLSAAK NEELLSPGYS QFSLPVQKKV MSTPLSKSNT 1320
LNSFSKIRKE ILKTPDSSKE KVNLQRFKEA LNSTFDYSEF SLEKSKSSGP MYLHKSCHSV 1380
EDGQLLTSNE SEDDEIFRRK VKRAKGNVLN SPEDQKNSEV DSPLHAVKKR RFPINRSELS 1440
SSDESENFPK PCSQLEDFKV CNGNARRGIK VPKRQSHLKH VARKFLDDEA ELSEEDAEYV 1500
SSDENDESEN EQDSSLLDFL NDETQLSQAI NDSEMRAIYM KSLRSPMMNN KYKMIHKTHK 1560
NINIFSQIPE QDETYLEDSF CVDEEESCKG QSSEEEVCVD FNLITDDCFA NSKKYKTRRA 1620
VMLKEMMEQN CAHSKKKLSR IILPDDSSEE ENNVNDKRES NIAVNPSTVK KNKQQDHCLN 1680
SVPSGSSAQS KVRSTPRVNP LAKQSKQTSL NLKDTISEVS DFKPQNHNEV QSTTPPFTTV 1740
DSQKDCRKFP VPQKDGSALE DSSTSGASCS KSRPHLAGTH TSLRLPQEGK GTCILVGGHE 1800
ITSGLEVISS LRAIHGLQVE VCPLNGCDYI VSNRMVVERR SQSEMLNSVN KNKFIEQIQH 1860
LQSMFERICV IVEKDREKTG DTSRMFRRTK SYDSLLTTLI GAGIRILFSS CQEETADLLK 1920
ELSLVEQRKN VGIHVPTVVN SNKSEALQFY LSIPNISYIT ALNMCHQFSS VKRMANSSLQ 1980
EISMYAQVTH QKAEEIYRYI HYVFDIQMLP NDLNQDRLKS DI 2022 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004518; F:nuclease activity; IEA:InterPro.
 GO:0006259; P:DNA metabolic process; IEA:InterPro.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR020819; DNA_repair_nuc_XPF/helicase.
 IPR006166; ERCC4_domain.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR011335; Restrct_endonuc-II-like.
 IPR010994; RuvA_2-like. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00891; ERCC4
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS