| Tag | Content |
|---|
| CPLM ID | CPLM-019282 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Scavenger receptor class F member 2 |
Protein Synonyms/Alias | SRECRP-1; Scavenger receptor expressed by endothelial cells 2 protein; SREC-II |
Gene Name | SCARF2 |
Gene Synonyms/Alias | SREC2; SREPCR |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 503 | RFSRISMKLPRIPLR | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity). |
Sequence Annotation | DOMAIN 71 110 EGF-like 1.
DOMAIN 122 153 EGF-like 2.
DOMAIN 148 182 EGF-like 3.
DOMAIN 183 212 EGF-like 4.
DOMAIN 213 241 EGF-like 5.
DOMAIN 236 270 EGF-like 6.
DOMAIN 372 403 EGF-like 7.
MOD_RES 651 651 Phosphoserine.
MOD_RES 653 653 Phosphoserine.
MOD_RES 718 718 Phosphoserine.
CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
CARBOHYD 365 365 N-linked (GlcNAc...) (Potential).
CARBOHYD 403 403 N-linked (GlcNAc...) (Potential).
DISULFID 75 86 By similarity.
DISULFID 80 98 By similarity.
DISULFID 100 109 By similarity.
DISULFID 126 134 By similarity.
DISULFID 128 141 By similarity.
DISULFID 143 152 By similarity.
DISULFID 156 163 By similarity.
DISULFID 158 170 By similarity.
DISULFID 172 181 By similarity.
DISULFID 185 193 By similarity.
DISULFID 187 200 By similarity.
DISULFID 202 211 By similarity.
DISULFID 215 222 By similarity.
DISULFID 217 229 By similarity.
DISULFID 231 240 By similarity.
DISULFID 244 251 By similarity.
DISULFID 246 258 By similarity.
DISULFID 260 269 By similarity.
DISULFID 376 384 By similarity.
DISULFID 379 391 By similarity.
DISULFID 393 402 By similarity. |
Keyword | Alternative splicing; Cell adhesion; Complete proteome; Disease mutation; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 870 AA |
Protein Sequence | MEGAGPRGAG PARRRGAGGP PSPLLPSLLL LLLLWMLPDT VAPQELNPRG RNVCRAPGSQ 60
VPTCCAGWRQ QGDECGIAVC EGNSTCSENE VCVRPGECRC RHGYFGANCD TKCPRQFWGP 120
DCKELCSCHP HGQCEDVTGQ CTCHARRWGA RCEHACQCQH GTCHPRSGAC RCEPGWWGAQ 180
CASACYCSAT SRCDPQTGAC LCHAGWWGRS CNNQCACNSS PCEQQSGRCQ CRERTFGARC 240
DRYCQCFRGR CHPVDGTCAC EPGYRGKYCR EPCPAGFYGL GCRRRCGQCK GQQPCTVAEG 300
RCLTCEPGWN GTKCDQPCAT GFYGEGCSHR CPPCRDGHAC NHVTGKCTRC NAGWIGDRCE 360
TKCSNGTYGE DCAFVCADCG SGHCDFQSGR CLCSPGVHGP HCNVTCPPGL HGADCAQACS 420
CHEDTCDPVT GACHLETNQR KGVMGAGALL VLLVCLLLSL LGCCCACRGK DPTRRPRPRR 480
ELSLGRKKAP HRLCGRFSRI SMKLPRIPLR RQKLPKVVVA HHDLDNTLNC SFLEPPSGLE 540
QPSPSWSSRA SFSSFDTTDE GPVYCVPHEE APAESRDPEV PTVPAEAPAP SPVPLTTPAS 600
AEEAIPLPAS SDSERSASSV EGPGGALYAR VARREARPAR ARGEIGGLSL SPSPERRKPP 660
PPDPATKPKV SWIHGKHSAA AAGRAPSPPP PGSEAAPSPS KRKRTPSDKS AHTVEHGSPR 720
TRDPTPRPPG LPEEATALAA PSPPRARARA APRPLGAHGR RRSPAKRAEA ASMLAADVRG 780
KTRSLGRAEV ALGAQGPREK PAPPQKAKRS VPPASPARAP PATETPGPEK AATDLPAPET 840
PRKKTPIQKP PRKKSREAAG ELGRAGAPTL 870 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005044; F:scavenger receptor activity; IEA:Compara. GO:0007157; P:heterophilic cell-cell adhesion; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |