UniProt Accession

 HMR1_HUMAN; Q95460; A8K2V9; B4E3B1; O97985; O97986; Q53GM1; Q95HB8; Q9NPL2; Q9TQB9; Q9TQK3 

Genbank Protein ID

 U22963; AJ249778; AK290374; AK304645; AK222910; AL356267; AL356267; AL356267; AL356267; CH471067; CH471067; CH471067; BC012485; AF010446; AF010447; AF031469; AH006983 

Genbank Nucleotide ID

 AAC50174.1; CAB77667.1; BAF83063.1; BAG65423.1; BAD96630.1; CAH72302.1; CAH72303.1; CAH72304.1; CAH72305.1; EAW91097.1; EAW91098.1; EAW91095.1; AAH12485.1; AAD01442.1; AAD01443.1; AAD01933.1; AAC72900.1 

Protein Name

 Major histocompatibility complex class I-related gene protein 

Protein Synonyms/Alias

 MHC class I-related gene protein; Class I histocompatibility antigen-like protein 

Gene Name

 MR1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
195	KRFLEYGKDTLQRTE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. 

Sequence Annotation

 DOMAIN 203 299 Ig-like C1-type.
 REGION 23 201 Ligand-binding.
 REGION 23 109 Alpha-1.
 REGION 110 201 Alpha-2.
 REGION 202 293 Alpha-3.
 REGION 294 302 Connecting peptide.
 CARBOHYD 107 107 N-linked (GlcNAc...).
 DISULFID 222 278 By similarity.  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; MHC I; Polymorphism; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 341 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0032393; F:MHC class I receptor activity; TAS:UniProtKB.
 GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
 GO:0006955; P:immune response; TAS:ProtInc. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.