UniProt Accession

 A2AFM8_MOUSE; A2AFM8 

Genbank Protein ID

 AL672150 

Genbank Nucleotide ID

  

Protein Name

 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 

Protein Synonyms/Alias

  

Gene Name

 Pfkfb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
91	QCALAALKDVHKYLS	ubiquitination	[1]
125	SLILQFAKEHGYKVF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0043540; C:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; IEA:Compara.
 GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:Compara.
 GO:0070095; F:fructose-6-phosphate binding; IEA:Compara.
 GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:Compara.
 GO:0006000; P:fructose metabolic process; IEA:InterPro.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0033133; P:positive regulation of glucokinase activity; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0033762; P:response to glucagon stimulus; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara. 

Interpro

 IPR003094; 6Pfruct_kin.
 IPR013079; 6Phosfructo_kin.
 IPR027417; P-loop_NTPase. 

Pfam

 PF01591; 6PF2K 

SMART

  

PROSITE

  

PRINTS

 PR00991; 6PFRUCTKNASE.