CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proenkephalin-B 
Protein Synonyms/Alias
 Beta-neoendorphin-dynorphin; Preprodynorphin; Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin; Big Dyn; Dynorphin A(1-17); Dyn-A17; Dynorphin A; Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin; Dynorphin B; Dyn-B; Dynorphin B(1-13); Leumorphin; Dynorphin B-29 
Gene Name
 PDYN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
118FLPSISTKENTLSKSacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). 
Sequence Annotation
  
Keyword
 Cleavage on pair of basic residues; Complete proteome; Disease mutation; Disulfide bond; Endorphin; Neurodegeneration; Neuropeptide; Neurotransmitter; Opioid peptide; Reference proteome; Secreted; Signal; Spinocerebellar ataxia. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 254 AA 
Protein Sequence
MAWQGLVLAA CLLMFPSTTA DCLSRCSLCA VKTQDGPKPI NPLICSLQCQ AALLPSEEWE 60
RCQSFLSFFT PSTLGLNDKE DLGSKSVGEG PYSELAKLSG SFLKELEKSK FLPSISTKEN 120
TLSKSLEEKL RGLSDGFREG AESELMRDAQ LNDGAMETGT LYLAEEDPKE QVKRYGGFLR 180
KYPKRSSEVA GEGDGDSMGH EDLYKRYGGF LRRIRPKLKW DNQKRYGGFL RRQFKVVTRS 240
QEDPNAYSGE LFDA 254 
Gene Ontology
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
 GO:0007268; P:synaptic transmission; IEA:UniProtKB-KW. 
Interpro
 IPR006024; Opioid_neupept.
 IPR000750; Proenkphlin_B. 
Pfam
 PF01160; Opiods_neuropep 
SMART
  
PROSITE
 PS01252; OPIOIDS_PRECURSOR 
PRINTS
 PR01028; OPIOIDPRCRSR.
 PR01030; PENKBPRCRSR.