| Tag | Content |
|---|
| CPLM ID | CPLM-016859 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/potassium/calcium exchanger 4 |
Protein Synonyms/Alias | Na(+)/K(+)/Ca(2+)-exchange protein 4 |
Gene Name | Slc24a4 |
Gene Synonyms/Alias | Nckx4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 333 | LRIMITNKFGPRTRL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). |
Sequence Annotation | REPEAT 139 179 Alpha-1.
REPEAT 495 526 Alpha-2.
CARBOHYD 69 69 N-linked (GlcNAc...) (Potential).
CARBOHYD 76 76 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Antiport; Calcium; Calcium transport; Complete proteome; Glycoprotein; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Repeat; Signal; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 622 AA |
Protein Sequence | MALRGLIRQS KVRRRREMLP QQVGFVCAVL ALVCCASGLF GSLGHKTASA GKHVLLDTWR 60
NRKLMAPING TPLAKNCTDP AIHEFPTDLF SNKERQHGAV LLHILGALYM FYALAIVCDD 120
FFVPSLEKIC EKLHLSEDVA GATFMAAGSS TPELFASVIG VFITHGDVGV GTIVGSAVFN 180
ILCIIGVCGL FAGQVVRLTW WAVCRDSVYY TLSVIVLIAF IYDEEIVWWE GLVLIILYVF 240
YILIMKYNMK MQTFFTTKQK SIANGNPVSN ELEDGNDLYD GSYDDPSVPL LGQVKEKPPY 300
GKTPVVMVDE ILSSSPPKFT FPEAGLRIMI TNKFGPRTRL RMASRIIINE RQRLINSANG 360
VNSKPLQNGR HENMENGNVP VENPEDPQQG QEQQPPPQPP PPEPESVETV FLSPFSMPEA 420
KGDKAKWVFT WPLIFLLCVT IPNCSKPRWE KFFMVTFITA TLWIAVFSYL MVWLVTIIGY 480
TLGIPDVIMG ITFLAAGTSV PDCMASLIVA RQGLGDMAVS NTIGSNVFDI LVGLGIPWGL 540
QTMVINYGST VKINSRGLVY SVVLLLGSVA LTVLGIHLNK WRLDRKLGIY VLVLYAVFLC 600
FSIMIEFNVF TFVNLPMCRE DD 622 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IC:MGI. GO:0008273; F:calcium, potassium:sodium antiporter activity; ISA:MGI. GO:0005432; F:calcium:sodium antiporter activity; ISA:MGI. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |