UniProt Accession

 FEZ1_MOUSE; Q8K0X8; Q3YE74 

Genbank Protein ID

 DQ141674; BC029629 

Genbank Nucleotide ID

 AAZ74351.1; AAH29629.1 

Protein Name

 Fasciculation and elongation protein zeta-1 

Protein Synonyms/Alias

 Zygin I; Zygin-1 

Gene Name

 Fez1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
306	LQSNRIEKGSQMPLK	acetylation	[1]
313	KGSQMPLKRFSMEGI	acetylation	[1]
376	AMKEDNEKVPTLLTD	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity). 

Sequence Annotation

 MOD_RES 58 58 Phosphoserine.
 MOD_RES 316 316 Phosphoserine.  

Keyword

 Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Microtubule; Phosphoprotein; Reference proteome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0005813; C:centrosome; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043015; F:gamma-tubulin binding; IDA:MGI.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0051654; P:establishment of mitochondrion localization; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR011680; FEZ.
 IPR015642; FEZ_1. 

Pfam

 PF07763; FEZ 

SMART

  

PROSITE

  

PRINTS