UniProt Accession

 ADH6_YEAST; Q04894; D6W0E6 

Genbank Protein ID

 Z54141; BK006946 

Genbank Nucleotide ID

 CAA90836.1; DAA10220.1 

Protein Name

 NADP-dependent alcohol dehydrogenase 6 

Protein Synonyms/Alias

 NADP-dependent alcohol dehydrogenase VI; ScADHVI 

Gene Name

 ADH6 

Gene Synonyms/Alias

 YMR318C; YM9924.10C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
25	WKNPKKTKYDPKPFY	acetylation	[1]
182	NGCGPGKKVGIVGLG	ubiquitination	[2]
200	SMGTLISKAMGAETY	ubiquitination	[2]
287	QHEMLSLKPYGLKAV	acetylation	[1]
356	FTLVGYDKEFSD***	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 NADP-dependent alcohol dehydrogenase with a broad substrate specificity. 

Sequence Annotation

 NP_BIND 187 192 NAD (By similarity).
 NP_BIND 275 277 NAD (By similarity).
 METAL 46 46 Zinc 1; catalytic (By similarity).
 METAL 68 68 Zinc 1; catalytic (By similarity).
 METAL 100 100 Zinc 2 (By similarity).
 METAL 103 103 Zinc 2 (By similarity).
 METAL 106 106 Zinc 2 (By similarity).
 METAL 114 114 Zinc 2 (By similarity).
 METAL 163 163 Zinc 1; catalytic (By similarity).
 BINDING 215 215 NAD (By similarity).
 BINDING 348 348 NAD (By similarity).
 MOD_RES 131 131 Phosphoserine.
 MOD_RES 359 359 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IDA:SGD.
 GO:0033833; F:hydroxymethylfurfural reductase (NADH) activity; IMP:SGD.
 GO:0033845; F:hydroxymethylfurfural reductase (NADPH) activity; IMP:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006066; P:alcohol metabolic process; IDA:SGD.
 GO:0033859; P:furaldehyde metabolic process; IMP:SGD. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS