UniProt Accession

 FA69B_HUMAN; Q5VUD6; Q5VUD7; Q8N5N0; Q8WYU5 

Genbank Protein ID

 AF318355; AL590226; AL355987; AL590226; AL355987; AL355987; AL590226; AL355987; AL590226; CH471090; BC032097 

Genbank Nucleotide ID

 AAL55862.1; CAH71724.1; CAH71724.1; CAH71725.1; CAH71725.1; CAI12696.1; CAI12696.1; CAI12700.1; CAI12700.1; EAW88253.1; AAH32097.1 

Protein Name

 Protein FAM69B 

Protein Synonyms/Alias

  

Gene Name

 FAM69B 

Gene Synonyms/Alias

 C9orf136; PP6977 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
195	RVSLAEAKSVWALLQ	ubiquitination	[1]
368	LIQPNLAKVCALLRG	acetylation	[2]
368	LIQPNLAKVCALLRG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 MOTIF 5 6 May mediate ER retention (By similarity).
 DISULFID 57 94 Probable.
 DISULFID 62 117 Probable.  

Keyword

 Alternative splicing; Complete proteome; Disulfide bond; Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 431 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR022049; Uncharacterised_FAM69. 

Pfam

 PF12260; PIP49_C 

SMART

  

PROSITE

  

PRINTS