UniProt Accession

 HBD_HUMAN; P02042; Q3Y5H3; Q8WXT7 

Genbank Protein ID

 U01317; V00505; AF339401; AF339402; AF339403; AF339404; AF339405; AF339406; AF339407; AF339408; AF339409; AF339410; AF339411; AF339412; AF339413; AF339414; AF339415; AF339416; AF339417; AY034468; DQ157442; BC069307; BC070282 

Genbank Nucleotide ID

 AAA16333.1; CAA23763.1; AAL72102.1; AAL72103.1; AAL72104.1; AAL72105.1; AAL72106.1; AAL72107.1; AAL72108.1; AAL72109.1; AAL72110.1; AAL72111.1; AAL72112.1; AAL72113.1; AAL72114.1; AAL72115.1; AAL72116.1; AAL72117.1; AAL72118.1; AAK68847.1; AAZ83699.1; AAH69307.1; AAH70282.1 

Protein Name

 Hemoglobin subunit delta 

Protein Synonyms/Alias

 Delta-globin; Hemoglobin delta chain 

Gene Name

 HBD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
145	VANALAHKYH*****	acetylation	[1, 2, 3]

Reference

 [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Involved in oxygen transport from the lung to the various peripheral tissues. 

Sequence Annotation

 METAL 64 64 Iron (heme distal ligand).
 METAL 93 93 Iron (heme proximal ligand).
 MOD_RES 2 2 N-acetylalanine; in variant Niigata.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005833; C:hemoglobin complex; TAS:ProtInc.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:InterPro.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome. 

Interpro

 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002337; Haemoglobin_b. 

Pfam

 PF00042; Globin 

SMART

  

PROSITE

 PS01033; GLOBIN 

PRINTS

 PR00814; BETAHAEM.