CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042307
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Malate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Mdh2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
91EQLPDCLKGSDVVVIacetylation[1]
165HGVYNPNKIFGVTTLacetylation[1]
185NTFVAELKGLDPARVacetylation[1]
203VIGGHAGKTIIPLISacetylation[1]
215LISQCTPKVDFPQDQacetylation[1]
239EAGTEVVKAKAGAGSacetylation[1]
281ECSFVQSKETECPYFacetylation[1]
296STPLLLGKNGLEKNLacetylation[1]
301LGKNGLEKNLGIGKIacetylation[1]
307EKNLGIGKISPFEEKacetylation[1]
314KISPFEEKMIAEAISacetylation[1]
324AEAISELKASIKKGEacetylation[1]
328SELKASIKKGEDFVKacetylation[1]
329ELKASIKKGEDFVKNacetylation[1]
335KKGEDFVKNMK****acetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; NAD; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 338 AA 
Protein Sequence
MLSAFARPTC AALRRSFSTS AQNNAKVAVL GASGGIGQPL SLLLKNSPLV SRLTLYDIAH 60
TPGVAADLSH IETRATVKGY LGPEQLPDCL KGSDVVVIPA GVPRKPGMTR DDLFNTNATI 120
VATLTAACAQ HCPEAMICII ANPVNSTIPI TAEVFKKHGV YNPNKIFGVT TLDIVRANTF 180
VAELKGLDPA RVSVPVIGGH AGKTIIPLIS QCTPKVDFPQ DQLATLVGRI QEAGTEVVKA 240
KAGAGSATLS MAYAGARFVF SLVDAMNGKE GVVECSFVQS KETECPYFST PLLLGKNGLE 300
KNLGIGKISP FEEKMIAEAI SELKASIKKG EDFVKNMK 338 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006475; P:internal protein amino acid acetylation; IEA:Compara.
 GO:0006108; P:malate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR001252; Malate_DH_AS.
 IPR010097; Malate_DH_type1.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 
SMART
  
PROSITE
 PS00068; MDH 
PRINTS