CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000603
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphomannomutase 1 
Protein Synonyms/Alias
 PMM 1 
Gene Name
 Pmm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
30TLTPARQKIDPEVSAubiquitination[1]
41EVSAFLQKLRSRVQIubiquitination[1]
171EKFVEALKTEFAGKGubiquitination[1]
177LKTEFAGKGLRFSRGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. 
Sequence Annotation
 ACT_SITE 19 19 Nucleophile (By similarity).
 ACT_SITE 21 21 By similarity.
 ACT_SITE 54 54 By similarity.
 ACT_SITE 198 198 By similarity.
 METAL 218 218 Magnesium (By similarity).
 BINDING 28 28 Substrate (By similarity).
 BINDING 132 132 Substrate (By similarity).
 BINDING 143 143 Substrate (By similarity).
 BINDING 150 150 Substrate (By similarity).
 BINDING 186 186 Substrate (By similarity).
 BINDING 188 188 Substrate (By similarity).
 BINDING 190 190 Substrate (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Isomerase; Magnesium; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 262 AA 
Protein Sequence
MAVAVEGARR KERILCLFDV DGTLTPARQK IDPEVSAFLQ KLRSRVQIGV VGGSDYSKIA 60
EQLGEGDEVI EKFDYVFAEN GTVQYKHGRL LSKQTIQNHL GEELLQDLIN FCLSYMALLR 120
LPKKRGTFIE FRNGMLNVSP IGRSCTLEER IEFSELDKKE KIREKFVEAL KTEFAGKGLR 180
FSRGGMISFD VFPEGWDKRY CLDSLDEDSF DIIHFFGNET SPGGNDFEIY ADPRTVGHSV 240
VSPQDTVQRC RELFFPETAH EA 262 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004615; F:phosphomannomutase activity; IEA:EC.
 GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019307; P:mannose biosynthetic process; IEA:InterPro. 
Interpro
 IPR023214; HAD-like_dom.
 IPR006379; HAD-SF_hydro_IIB.
 IPR005002; PMM. 
Pfam
 PF03332; PMM 
SMART
  
PROSITE
  
PRINTS