UniProt Accession

 YIDC_ECOLI; P25714; Q2M818 

Genbank Protein ID

 L10328; U00096; AP009048; M11056 

Genbank Nucleotide ID

 AAA62056.1; AAC76728.1; BAE77588.1 

Protein Name

 Membrane protein insertase YidC 

Protein Synonyms/Alias

 Foldase YidC; Inner membrane protein YidC; Membrane integrase YidC; Oxa1Ec 

Gene Name

 yidC 

Gene Synonyms/Alias

 b3705; JW3683 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
234	DEKYEKYKFDTIADN	acetylation	[1]
389	KMRMLQPKIQAMRER	acetylation	[1]
401	RERLGDDKQRISQEM	acetylation	[1]
413	QEMMALYKAEKVNPL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F(0)ATP synthase, FtsQ and SecE proteins and for Sec-independent subunit c of the F(0)ATP synthase, M13 phage procoat and the N-terminus of leader peptidase Lep. Probably interacts directly with Sec-independent substrates. Sec-dependent protein FtsQ interacts first with SecY then subsequently with YidC. Sec-dependent LacY and MalF require YidC to acquire tertiary structure and stability, a chaperone-like function, but not for membrane insertion. Stable maltose transport copmplex formation (MalFGK(2)) also requires YidC. Partially complements a Streptococcus mutans yidC2 disruption mutant. 

Sequence Annotation

 REGION 24 264 Can be removed without causing lethality,
 REGION 215 265 Interacts with SecF; not required for
 REGION 265 346 Required for Sec-dependent and Sec-
 REGION 527 548 Can be removed without causing lethality,  

Keyword

 3D-structure; Cell inner membrane; Cell membrane; Chaperone; Complete proteome; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 548 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0032977; F:membrane insertase activity; IMP:EcoliWiki.
 GO:0006461; P:protein complex assembly; IMP:UniProtKB.
 GO:0006457; P:protein folding; IMP:UniProtKB.
 GO:0051205; P:protein insertion into membrane; IDA:EcoliWiki. 

Interpro

 IPR019998; Membr_insert_YidC.
 IPR001708; Membrane_insert_OXA1/ALB3/YidC. 

Pfam

 PF02096; 60KD_IMP 

SMART

  

PROSITE

  

PRINTS

 PR00701; 60KDINNERMP.
 PR01900; YIDCPROTEIN.