CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031102
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTP-binding protein SAR1a 
Protein Synonyms/Alias
 cDNA FLJ58922, highly similar to GTP-binding protein SAR1a 
Gene Name
 SAR1A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
103TDAISEEKLREIFGLacetylation[1, 2, 3]
103TDAISEEKLREIFGLubiquitination[3, 4, 5]
123GKGNVTLKELNARPMubiquitination[3, 5, 6]
139VFMCSVLKRQGYGEGubiquitination[5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 155 AA 
Protein Sequence
MLKDDRLGQH VPTLHPTSEE LTIAGMTFTT FDLGGHEQAR RVWKNYLPAI NGIVFLVDCA 60
DHSRLVESKV ELNALMTDET ISNVPILILG NKIDRTDAIS EEKLREIFGL YGQTTGKGNV 120
TLKELNARPM EVFMCSVLKR QGYGEGFRWL SQYID 155 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016529; C:sarcoplasmic reticulum; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:Compara. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR006689; Small_GTPase_ARF/SAR.
 IPR006687; Small_GTPase_SAR1. 
Pfam
 PF00025; Arf 
SMART
 SM00178; SAR 
PROSITE
 PS51422; SAR1 
PRINTS
 PR00328; SAR1GTPBP.