Tag | Content |
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CPLM ID | CPLM-021877 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cdc42 effector protein 4 |
Protein Synonyms/Alias | Binder of Rho GTPases 4 |
Gene Name | Cdc42ep4 |
Gene Synonyms/Alias | Borg4; Cep4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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15 | VSSSVNSKRRSRADL | ubiquitination | [1] | 56 | DTSFLTSKAREADDE | ubiquitination | [1] | 112 | RDSALFVKNAMSLPQ | ubiquitination | [1] | 123 | SLPQLNEKEAAEKDS | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
Sequence Annotation | DOMAIN 27 41 CRIB. MOD_RES 64 64 Phosphoserine. MOD_RES 107 107 Phosphoserine. MOD_RES 116 116 Phosphoserine (By similarity). MOD_RES 136 136 Phosphoserine (By similarity). MOD_RES 138 138 Phosphoserine (By similarity). MOD_RES 139 139 Phosphoserine. MOD_RES 140 140 Phosphoserine (By similarity). MOD_RES 154 154 Phosphoserine. MOD_RES 165 165 Phosphoserine (By similarity). MOD_RES 223 223 Phosphoserine. MOD_RES 285 285 Phosphoserine (By similarity). MOD_RES 288 288 Phosphoserine (By similarity). |
Keyword | Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 349 AA |
Protein Sequence | MPILKQLVSS SVNSKRRSRA DLTAEMISAP LGDFRHTMHV GRAGDAFGDT SFLTSKAREA 60 DDESLDEQAS ASKLSLLSRK FRGSKRSQSV TRGDREQRDM LGSLRDSALF VKNAMSLPQL 120 NEKEAAEKDS SKLPKSLSSS PVKKADARDG GPKSPHRNGA TGPHSPDPLL DEQAFGDLMD 180 LPIMPKVSYG LKHAESILSF HIDLGPSMLG DVLSIMDKDQ WGSEEEEEAG GYRDKEGPSS 240 IVQAPPVLEV VPPLGRQESK ASWDQASMLP PHAVEDDGWA VVAPSPSSAR SVGSHTTRDS 300 SSLSSYTSGV LEERSPAFRG PDRVAAAPPR QPDKEFCFMD EEEEDEIRV 349 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; IEA:Compara. GO:0005737; C:cytoplasm; IDA:MGI. GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-KW. GO:0015630; C:microtubule cytoskeleton; IEA:Compara. GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Compara. GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. GO:0007266; P:Rho protein signal transduction; IDA:MGI. |
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