| Tag | Content |
|---|
| CPLM ID | CPLM-024519 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase MARCH11 |
Protein Synonyms/Alias | Membrane-associated RING finger protein 11; Membrane-associated RING-CH protein XI; MARCH-XI |
Gene Name | MARCH11 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 82 | WDVLNYDKATDIEES | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity). |
Sequence Annotation | ZN_FING 162 222 RING-CH-type.
MOTIF 371 374 YXXL motif.
MOTIF 399 402 PDZ-binding. |
Keyword | Alternative splicing; Complete proteome; Cytoplasmic vesicle; Ligase; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 402 AA |
Protein Sequence | MIAVILGSLF LIASVTWLLW SAFSPYAVWQ RKDILFQICY GMYGFMDLVC IGLIVHEGAA 60
VYRVFKRWRA VNLHWDVLNY DKATDIEESS RGESSTSRTL WLPLTALRNR NLVHPTQLTS 120
PRFQCGYVLL HLFNRMRPHE DLSEDNSSGE VVMRVTSV 158 |
Gene Ontology | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |