CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025078
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Enoyl-CoA delta isomerase 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Eci2 
Gene Synonyms/Alias
 Peci 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
273CSSYTFPKMMGSAKAacetylation[1]
273CSSYTFPKMMGSAKAsuccinylation[1]
273CSSYTFPKMMGSAKAubiquitination[2]
323TRLKTYAKLPPNAMRacetylation[3]
343IRKNEKEKLYAVNAEacetylation[4]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 378 AA 
Protein Sequence
MLVSEVFRLQ VAKLHLGRPT MRASQQDFEN ALNQVKLLKK DPGNEVKLRL YALYKQATEG 60
PCNMPKPGML DFVNKAKWDA WNALGSLPKE TARQNYVDLV SSLSSSSEAP SQGKRGADEK 120
ARESKDILVT SEDGITKITF NRPTKKNAIS FQMYRDIILA LKNASTDNTV MAVFTGTGDY 180
YCSGNDLTNF TSATGGIEEA ASNGAVLLRD FVNSFIDFPK PLVAVVNGPA VGISVTLLGL 240
FDAVFASDRA TFHTPFSQLG QSPEACSSYT FPKMMGSAKA AEMLLFGKKL TAREAWAQGL 300
VTEVFPESTF ETEVWTRLKT YAKLPPNAMR ISKELIRKNE KEKLYAVNAE ECTTLQARWL 360
SEECMNAIMS FVSRKPKL 378 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro. 
Interpro
 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR001753; Crotonase_core_superfam.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. 
Pfam
 PF00887; ACBP
 PF00378; ECH 
SMART
  
PROSITE
 PS00880; ACB_1
 PS51228; ACB_2 
PRINTS
 PR00689; ACOABINDINGP.