UniProt Accession

 EFTS_MOUSE; Q9CZR8; Q3TFF5 

Genbank Protein ID

 AK012240; AK169164; BC057904 

Genbank Nucleotide ID

 BAB28113.1; BAE40943.1; AAH57904.1 

Protein Name

 Elongation factor Ts, mitochondrial 

Protein Synonyms/Alias

 EF-Ts; EF-TsMt 

Gene Name

 Tsfm 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
75	ETCGGDLKQAEDWLH	acetylation	[1]
83	QAEDWLHKQAQKEGW	acetylation	[1]
95	EGWSKAAKLHGRKTK	acetylation	[1]
132	DFVSRNLKFQQLVQQ	acetylation	[1]
191	QLALAIGKLGENMIL	acetylation	[2]
191	QLALAIGKLGENMIL	succinylation	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Elongation factor; Mitochondrion; Protein biosynthesis; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 324 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003746; F:translation elongation factor activity; IEA:HAMAP. 

Interpro

 IPR001816; Transl_elong_EFTs/EF1B.
 IPR014039; Transl_elong_EFTs/EF1B_dimer.
 IPR018101; Transl_elong_Ts_CS.
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N. 

Pfam

 PF00889; EF_TS
 PF00627; UBA 

SMART

  

PROSITE

 PS01126; EF_TS_1
 PS01127; EF_TS_2 

PRINTS