UniProt Accession

 MCL1_MOUSE; P97287; D2K6L9; Q3TUS0; Q792P0; Q9CRI4 

Genbank Protein ID

 U35623; GU182318; AK010424; AK159504; AK160594; AC092479; FO082281; BC003839; BC005427; BC021638; AF063886 

Genbank Nucleotide ID

 AAC31790.1; ACZ54910.1; BAB26927.1; BAE35137.1; BAE35901.1; AAH03839.1; AAH05427.1; AAH21638.1; AAC27929.1 

Protein Name

 Induced myeloid leukemia cell differentiation protein Mcl-1 homolog 

Protein Synonyms/Alias

 Bcl-2-related protein EAT/mcl1 

Gene Name

 Mcl1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
219	MLRKLDIKNEGDVKS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. 

Sequence Annotation

 REGION 85 156 PEST-like (By similarity).
 MOTIF 190 204 BH3.
 MOTIF 234 253 BH1.
 MOTIF 285 300 BH2.
 MOD_RES 102 102 Phosphoserine (By similarity).
 MOD_RES 143 143 Phosphoserine (By similarity).
 MOD_RES 144 144 Phosphothreonine; by MAPK (By
 CROSSLNK 117 117 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 175 175 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 178 178 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Isopeptide bond; Membrane; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0097136; C:Bcl-2 family protein complex; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; ISO:MGI.
 GO:0005759; C:mitochondrial matrix; IDA:MGI.
 GO:0005739; C:mitochondrion; ISO:MGI.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:2000811; P:negative regulation of anoikis; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Compara.
 GO:2001020; P:regulation of response to DNA damage stimulus; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara. 

Interpro

 IPR013281; Apop_reg_Mc1.
 IPR002475; Bcl2-like.
 IPR020717; Bcl2_BH1_motif_CS.
 IPR020726; Bcl2_BH2_motif_CS.
 IPR020728; Bcl2_BH3_motif_CS.
 IPR026298; Blc2_fam. 

Pfam

 PF00452; Bcl-2 

SMART

  

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2
 PS01259; BH3 

PRINTS

 PR01866; APOPREGMCL1.
 PR01862; BCL2FAMILY.