UniProt Accession

 TEAD2_HUMAN; Q15562; B4DTJ6; Q8NA25; Q96IG3 

Genbank Protein ID

 AK093236; AK290736; AK300241; AC010524; CH471177; BC051301; BC007556; X94440 

Genbank Nucleotide ID

 BAC04104.1; BAF83425.1; BAG62008.1; EAW52469.1; AAH51301.1; AAH07556.1; CAA64214.1 

Protein Name

 Transcriptional enhancer factor TEF-4 

Protein Synonyms/Alias

 TEA domain family member 2; TEAD-2 

Gene Name

 TEAD2 

Gene Synonyms/Alias

 TEF4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
75	IILSDEGKMYGRNEL	ubiquitination	[1]
125	KLKDQVSKDKAFQTM	ubiquitination	[2]
127	KDQVSKDKAFQTMAT	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. 

Sequence Annotation

 DNA_BIND 40 107 TEA.
 REGION 172 447 Transcriptional activation (Potential).  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 447 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0003143; P:embryonic heart tube morphogenesis; IEA:Compara.
 GO:0035329; P:hippo signaling cascade; IDA:UniProtKB.
 GO:0048368; P:lateral mesoderm development; IEA:Compara.
 GO:0060548; P:negative regulation of cell death; IEA:Compara.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0030903; P:notochord development; IEA:Compara.
 GO:0048339; P:paraxial mesoderm development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0001570; P:vasculogenesis; IEA:Compara. 

Interpro

 IPR000818; TEA/ATTS.
 IPR016361; TEF. 

Pfam

 PF01285; TEA 

SMART

 SM00426; TEA 

PROSITE

 PS00554; TEA_1
 PS51088; TEA_2 

PRINTS

 PR00065; TEADOMAIN.