UniProt Accession

 KPRS_SALTY; P0A1V6; P15849 

Genbank Protein ID

 M19488; AE006468 

Genbank Nucleotide ID

 AAA27196.1; AAL20695.1 

Protein Name

 Ribose-phosphate pyrophosphokinase 

Protein Synonyms/Alias

 RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase 

Gene Name

 prs 

Gene Synonyms/Alias

 prsA; STM1780 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
5	***MPDMKLFAGNAT	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 REGION 213 226 Binding of phosphoribosylpyrophosphate
 METAL 129 129 Magnesium (Potential).
 METAL 131 131 Magnesium (Potential).
 METAL 140 140 Magnesium (Potential).
 METAL 144 144 Magnesium (Potential).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:HAMAP.
 GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
 GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:HAMAP. 

Interpro

 IPR000842; PRib_PP_synth_CS.
 IPR000836; PRibTrfase_dom.
 IPR005946; Rib-P_diPkinase. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00114; PRPP_SYNTHASE 

PRINTS