UniProt Accession

 PUSL1_HUMAN; Q8N0Z8; B4DP76; Q5TA41 

Genbank Protein ID

 AK075292; AK298218; AL139287; CH471183; BC034304 

Genbank Nucleotide ID

 BAC11527.1; BAG60488.1; CAI23172.1; EAW56245.1; AAH34304.1 

Protein Name

 tRNA pseudouridine synthase-like 1 

Protein Synonyms/Alias

 tRNA pseudouridylate synthase-like 1; tRNA-uridine isomerase-like 1 

Gene Name

 PUSL1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
266	ESQDPLGKHQTRVAP	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 ACT_SITE 66 66 Nucleophile (By similarity).
 BINDING 130 130 Substrate (By similarity).
 MOD_RES 84 84 Phosphoserine.
 MOD_RES 100 100 Phosphothreonine.  

Keyword

 Alternative splicing; Complete proteome; Isomerase; Phosphoprotein; Polymorphism; Reference proteome; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR020103; PsdUridine_synth_cat_dom.
 IPR001406; PsdUridine_synth_TruA.
 IPR020097; PsdUridine_synth_TruA_a/b_dom.
 IPR020095; PsdUridine_synth_TruA_C.
 IPR020094; PsdUridine_synth_TruA_N. 

Pfam

 PF01416; PseudoU_synth_1 

SMART

  

PROSITE

  

PRINTS