CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017576
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Procollagen galactosyltransferase 1 
Protein Synonyms/Alias
 Collagen beta(1-O)galactosyltransferase 1; Glycosyltransferase 25 family member 1; Hydroxylysine galactosyltransferase 1 
Gene Name
 COLGALT1 
Gene Synonyms/Alias
 GLT25D1; PSEC0241 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145SRYEHVMKLRQAALKubiquitination[1]
508ISLQGARKLLAAEPLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen. 
Sequence Annotation
 MOTIF 619 622 Prevents secretion from ER.
 CARBOHYD 96 96 N-linked (GlcNAc...).
 CARBOHYD 184 184 N-linked (GlcNAc...) (Potential).
 CARBOHYD 381 381 N-linked (GlcNAc...).  
Keyword
 Complete proteome; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Reference proteome; Signal; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 622 AA 
Protein Sequence
MAAAPRAGRR RGQPLLALLL LLLAPLPPGA PPGADAYFPE ERWSPESPLQ APRVLIALLA 60
RNAAHALPTT LGALERLRHP RERTALWVAT DHNMDNTSTV LREWLVAVKS LYHSVEWRPA 120
EEPRSYPDEE GPKHWSDSRY EHVMKLRQAA LKSARDMWAD YILFVDADNL ILNPDTLSLL 180
IAENKTVVAP MLDSRAAYSN FWCGMTSQGY YKRTPAYIPI RKRDRRGCFA VPMVHSTFLI 240
DLRKAASRNL AFYPPHPDYT WSFDDIIVFA FSCKQAEVQM YVCNKEEYGF LPVPLRAHST 300
LQDEAESFMH VQLEVMVKHP PAEPSRFISA PTKTPDKMGF DEVFMINLRR RQDRRERMLR 360
ALQAQEIECR LVEAVDGKAM NTSQVEALGI QMLPGYRDPY HGRPLTKGEL GCFLSHYNIW 420
KEVVDRGLQK SLVFEDDLRF EIFFKRRLMN LMRDVEREGL DWDLIYVGRK RMQVEHPEKA 480
VPRVRNLVEA DYSYWTLAYV ISLQGARKLL AAEPLSKMLP VDEFLPVMFD KHPVSEYKAH 540
FSLRNLHAFS VEPLLIYPTH YTGDDGYVSD TETSVVWNNE HVKTDWDRAK SQKMREQQAL 600
SREAKNSDVL QSPLDSAARD EL 622 
Gene Ontology
 GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB.
 GO:0050211; F:procollagen galactosyltransferase activity; IEA:EC.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro. 
Interpro
 IPR002654; Glyco_trans_25. 
Pfam
 PF01755; Glyco_transf_25 
SMART
  
PROSITE
 PS00014; ER_TARGET 
PRINTS