CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026765
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphoribosylamine--glycine ligase 
Protein Synonyms/Alias
 GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase 
Gene Name
 garS 
Gene Synonyms/Alias
 purD; RPA1162 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
151ADGLAAGKGVVVAMTacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
  
Sequence Annotation
 DOMAIN 107 312 ATP-grasp (By similarity).
 NP_BIND 133 193 ATP (By similarity).
 METAL 282 282 Magnesium or manganese (By similarity).
 METAL 284 284 Magnesium or manganese (By similarity).  
Keyword
 ATP-binding; Complete proteome; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Purine biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 427 AA 
Protein Sequence
MNILLLGSGG REHALAWKIA ASPLVTKLWC APGNAGIARE ATCVALDIGN HQAVVEFCKA 60
NAVDLVVVGP EAPLAAGIVD DLAAAGIKAF GPSRKASQLE SSKGFTKDLC KAHDIPTAAY 120
ERFGDPNQAK TYIRAQGAPI VIKADGLAAG KGVVVAMTVA EAEAAVDMMF GGGLGSAGVE 180
VVVEDFLVGE EASFFVLCDG EHALPLATAQ DHKRAYDGDK GPNTGGMGAY SPAPVMTDAI 240
CQQAMQRIIY PTLKAMKAMG APFKGVLFAG LMITDEGPQL IEYNVRFGDP ECQVLMMRMM 300
SDIVPALLAC ADGQLDHFSL RWHDEPALTV VMAAKGYPGT YEKGTRIAGL ERADAIAGVQ 360
IFHAGTIASG DWILANGGRV LAVTASAKTV AEAQRRAYEA IGVINWPEGF CRRDIGWQAV 420
ARERRGK 427 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0030145; F:manganese ion binding; IEA:HAMAP.
 GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:HAMAP.
 GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro. 
Interpro
 IPR011761; ATP-grasp.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR016185; PreATP-grasp_dom.
 IPR020561; PRibGlycinamid_synth_ATP-grasp.
 IPR000115; PRibGlycinamide_synth.
 IPR020560; PRibGlycinamide_synth_C-dom.
 IPR020559; PRibGlycinamide_synth_CS.
 IPR020562; PRibGlycinamide_synth_N.
 IPR011054; Rudment_hybrid_motif. 
Pfam
 PF01071; GARS_A
 PF02843; GARS_C
 PF02844; GARS_N 
SMART
  
PROSITE
 PS50975; ATP_GRASP
 PS00184; GARS 
PRINTS