CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038086
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear receptor coactivator 2 
Protein Synonyms/Alias
 Uncharacterized protein 
Gene Name
 Ncoa2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
279TRQDLQGKITSLDTSubiquitination[1]
636HSRLHDSKGQTKLLQacetylation[2, 3]
640HDSKGQTKLLQLLTTacetylation[2, 3, 4]
640HDSKGQTKLLQLLTTubiquitination[1]
648LLQLLTTKSDQMEPSacetylation[4]
705SSPVDLAKLTAEATGacetylation[4]
713LTAEATGKELSQESSacetylation[4]
765GLPEITPKLERLDSKacetylation[3, 4]
772KLERLDSKTDPASNTacetylation[2, 3]
780TDPASNTKLIAMKTVacetylation[2, 3, 4]
785NTKLIAMKTVKEEVSacetylation[2, 3, 4]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1393 AA 
Protein Sequence
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA ELIFANFNDI 60
DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS DVSSTGQGVI DKDALGPMML 120
EALDGFFFVV NLEGSVVFVS ENVTQYLRYN QEELMNKSVY SILHVGDHTE FVKNLLPKSM 180
VNGGSWSGEP PRRSSHTFNC RMLVKPLPDS EEEGHDSQEA HQKYEAMQCF AVSQPKSIKE 240
EGEDLQSCLI CVARRVPMKE RPTLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV 300
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ TKSKLIRSQT 360
TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLNPISS SSPAHQALCS GNPGQDMTLG 420
SNINFPMNGP KEQMGMPMGR FGGSGGMNHV SGMQATTPQG SNYALKMNSP SQSSPGMNPG 480
QASSVLSPRQ RMSPGVAGSP RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL 540
SEGHGVSLGS SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 600
EASCHPEEQK GPNDSSMPQA ASGDRAEGHS RLHDSKGQTK LLQLLTTKSD QMEPSPLPSS 660
LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP VDLAKLTAEA TGKELSQESS 720
STAPGSEVTV KQEPASPKKK ENALLRYLLD KDDTKDIGLP EITPKLERLD SKTDPASNTK 780
LIAMKTVKEE VSFEPSDQPG SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII 840
NDLMQLTADS SPVPPAGAQK AALRMSQSRM IGSSTSRPSM PSGEWAPQSP AVRVTCAATT 900
GAMNRPVQGG MIRNPTASIP MRANSQPGQR QMLQSQVMNI GPSELEMNMG GPQYNQQQAP 960
PNQTAPWPES ILPIDQASFA SQNRQPFGSS PDDLLCPHPA AESPSDEGAL LDQLYLALRN 1020
FDGLEEIDRA LGIPELVSQS QAVDAEQFSS QESSIMLEQK PPVFPQQYAS QAQMAQGGYN 1080
PMQDPNFHTM GQRPNYTTLR MQPRPGLRPT GIVQNQPNQL RLQLQHRLQA QQNRQPLMNQ 1140
ISSVSNVNLT LRPGVPTQAP INAQMLAQRQ REILNQHLRQ RQMQQQVQQR TLMMRGQGLN 1200
VTPSMVAPAG LPAAMSNPRI PQANAQQFPF PPNYGISQQP DPGFTGATTP QSPLMSPRMA 1260
HTQSPMMQQS QANPAYQPTS DMNGWAQGSM GGNSMFSQQS PPHFGQQANT SMYSNNMNIS 1320
VSMATNTGGL SSMNQMTGQM SMTSVTSVPT SGLPSMGPEQ VNDPALRGGN LFPNQLPGMD 1380
MIKQEGDASR KYC 1393 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
 GO:0005102; F:receptor binding; IDA:MGI.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0030375; F:thyroid hormone receptor coactivator activity; IDA:MGI.
 GO:0016573; P:histone acetylation; IEA:GOC.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011598; bHLH_dom.
 IPR010011; DUF1518.
 IPR009110; Nuc_rcpt_coact.
 IPR014920; Nuc_rcpt_coact_Ncoa-typ.
 IPR017426; Nuclear_rcpt_coactivator.
 IPR001610; PAC.
 IPR000014; PAS.
 IPR013767; PAS_fold.
 IPR014935; SRC-1.
 IPR008955; Src1_rcpt_coact. 
Pfam
 PF07469; DUF1518
 PF08815; Nuc_rec_co-act
 PF00989; PAS
 PF08832; SRC-1 
SMART
 SM00353; HLH
 SM00086; PAC
 SM00091; PAS 
PROSITE
 PS50888; BHLH
 PS50112; PAS 
PRINTS