Tag | Content |
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CPLM ID | CPLM-017862 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein HEXIM1 |
Protein Synonyms/Alias | Cardiac lineage protein 1 |
Gene Name | Hexim1 |
Gene Synonyms/Alias | Clp1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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286 | MSKQELIKEYLELEK | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (By similarity). |
Sequence Annotation | REGION 147 174 Basic region; mediates nuclear REGION 199 202 Interaction with P-TEFb (By similarity). REGION 207 247 Autoinhibitory acidic region; in absence REGION 283 311 Mediates interaction with CCNT1 (By REGION 307 352 Required for inhibition of ESR1-dependent MOD_RES 98 98 Phosphoserine (By similarity). MOD_RES 230 230 Phosphoserine (By similarity). MOD_RES 233 233 Phosphothreonine (By similarity). MOD_RES 234 234 Phosphoserine (By similarity). MOD_RES 249 249 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 356 AA |
Protein Sequence | MAEPLLTEHQ HQPQTSNCTG AAVVHEEHTS ERPPSAEERV PKEDSRWQSR ASLQSGSRPG 60 QEGEGGLKHQ LPPLQTNACP ELSSLEKGEK GQNGEDLSTG GASPSAEGEP MSESLVQPGH 120 DSEATKQEAP AAGGEEPWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKFDEKQS 180 LRASRVRAEM FAKGQPVAPY NTTQFLMDDH DQEEPDLKTG LYPKRAAAKS DDTSDEDFVE 240 EAGEEDGGSD GMGGDGSEFL QRDFSETYER YHAESLQNMS KQELIKEYLE LEKCLSRKED 300 ENNRLRLESK RLGGVDARVR ELELELDRLR AENLQLLTEN ELHRQQERAP LSKFGD 356 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; ISS:UniProtKB. GO:0017069; F:snRNA binding; ISS:UniProtKB. GO:0007507; P:heart development; IMP:MGI. GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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