UniProt Accession

 RL4A_YEAST; P10664; D6VQ32 

Genbank Protein ID

 X76078; J03195; Z35900; BK006936 

Genbank Nucleotide ID

 CAA53687.1; AAA34974.1; CAA84973.1; DAA07152.1 

Protein Name

 60S ribosomal protein L4-A 

Protein Synonyms/Alias

 L2; RP2; YL2 

Gene Name

 RPL4A 

Gene Synonyms/Alias

 RPL2; RPL2A; YBR031W; YBR0315 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
55	QAYAVSEKAGHQTSA	ubiquitination	[1, 2]
104	GRMFAPTKTWRKWNV	acetylation	[3]
104	GRMFAPTKTWRKWNV	methylation	[4]
104	GRMFAPTKTWRKWNV	ubiquitination	[2]
112	TWRKWNVKVNHNEKR	acetylation	[3]
144	ARGHRVEKIPEIPLV	acetylation	[3]
144	ARGHRVEKIPEIPLV	ubiquitination	[1, 2]
161	TDLESIQKTKEAVAA	acetylation	[3]
163	LESIQKTKEAVAALK	ubiquitination	[2]
170	KEAVAALKAVGAHSD	acetylation	[3]
170	KEAVAALKAVGAHSD	ubiquitination	[2]
180	GAHSDLLKVLKSKKL	acetylation	[3]
217	AEDNGIVKALRNVPG	acetylation	[3]
217	AEDNGIVKALRNVPG	ubiquitination	[1, 2]
257	WTEAAFTKLDQVWGS	ubiquitination	[2]
271	SETVASSKVGYTLPS	ubiquitination	[1, 2]
308	PAGQATQKRTHVLKK	ubiquitination	[1, 2]
321	KKNPLKNKQVLLRLN	acetylation	[3]
321	KKNPLKNKQVLLRLN	ubiquitination	[2]
332	LRLNPYAKVFAAEKL	acetylation	[3]
332	LRLNPYAKVFAAEKL	ubiquitination	[2]
338	AKVFAAEKLGSKKAE	acetylation	[3]
338	AKVFAAEKLGSKKAE	ubiquitination	[2]
343	AEKLGSKKAEKTGTK	acetylation	[5]
360	AVFTETLKHD*****	acetylation	[3]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [4] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.
 Pang CN, Gasteiger E, Wilkins MR.
 BMC Genomics. 2010 Feb 5;11:92. [PMID: 20137074]
 [5] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591] 

Functional Description

 Participates in the regulation of the accumulation of its own mRNA. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; TAS:SGD.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; TAS:SGD.
 GO:0002181; P:cytoplasmic translation; TAS:SGD. 

Interpro

 IPR025755; Ribos_L4_C_dom.
 IPR002136; Ribosomal_L4/L1e.
 IPR013000; Ribosomal_L4/L1e_euk/arc_CS.
 IPR023574; Ribosomal_L4_dom. 

Pfam

 PF14374; Ribos_L4_asso_C
 PF00573; Ribosomal_L4 

SMART

  

PROSITE

 PS00939; RIBOSOMAL_L1E 

PRINTS