CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032389
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MAGUK p55 subfamily member 6 
Protein Synonyms/Alias
 Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6), isoform CRA_a; Uncharacterized protein 
Gene Name
 MPP6 
Gene Synonyms/Alias
 hCG_38837 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
83KELQELLKNISGSVTubiquitination[1, 2, 3]
133EAGLKFSKGEILQIVubiquitination[2]
291EADIKAGKYLEHGEYubiquitination[1, 2, 3, 4]
403IINDNLDKAFEKLQTubiquitination[1, 3]
407NLDKAFEKLQTAIEKubiquitination[1, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 428 AA 
Protein Sequence
MNNSSINNQL LPVDAIRILG IHKRAGEPLG VTFRVENNDL VIARILHGGM IDRQGLLHVG 60
DIIKEVNGHE VGNNPKELQE LLKNISGSVT LKILPSYRDT ITPQQVFVKC HFDYNPYNDN 120
LIPCKEAGLK FSKGEILQIV NREDPNWWQA SHVKEGGSAG LIPSQFLEEK RKAFVRRDWD 180
NSGPFCGTIS SKKKKKMMYL TTRNAEFDRH EIQIYEEVAK MPPFQRKTLV LIGAQGVGRR 240
SLKNRFIVLN PTRFGTTVPF TSRKPREDEK DGQAYKFVSR SEMEADIKAG KYLEHGEYEG 300
NLYGTKIDSI LEVVQTGRTC ILDVNPQALK VLRTSEFMPY VVFIAAPELE TLRAMHKAVV 360
DAGITTKLLT DSDLKKTVDE SARIQRAYNH YFDLIIINDN LDKAFEKLQT AIEKLRMEPQ 420
WVPISWVY 428 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:Compara. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF00595; PDZ
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 
PRINTS