UniProt Accession

 MMS2_YEAST; P53152; D6VU57 

Genbank Protein ID

 U66724; Z72609; BK006941 

Genbank Nucleotide ID

 AAC24241.1; CAA96792.1; DAA08018.1 

Protein Name

 Ubiquitin-conjugating enzyme variant MMS2 

Protein Synonyms/Alias

 UEV MMS2 

Gene Name

 MMS2 

Gene Synonyms/Alias

 YGL087C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
16	RLLEELEKGEKGFGP	acetylation	[1]
132	NKKLRQPKEGETF**	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The UBC13/MMS2 heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through 'Lys-63'. 

Sequence Annotation

 MOD_RES 71 71 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Ligase; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0031371; C:ubiquitin conjugating enzyme complex; IPI:SGD.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:SGD.
 GO:0010994; P:free ubiquitin chain polymerization; IDA:SGD.
 GO:0006301; P:postreplication repair; IMP:SGD.
 GO:0000209; P:protein polyubiquitination; IPI:SGD. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS