CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003357
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Regulatory protein AsnC 
Protein Synonyms/Alias
  
Gene Name
 asnC 
Gene Synonyms/Alias
 b3743; JW3721 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
30TAYAELAKQFGVSPGacetylation[1]
80GIILKSAKDYPSALAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level. 
Sequence Annotation
 DOMAIN 6 67 HTH asnC-type.
 DNA_BIND 25 44 H-T-H motif (Potential).  
Keyword
 3D-structure; Activator; Complete proteome; DNA-binding; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 152 AA 
Protein Sequence
MENYLIDNLD RGILEALMGN ARTAYAELAK QFGVSPGTIH VRVEKMKQAG IITGARIDVS 60
PKQLGYDVGC FIGIILKSAK DYPSALAKLE SLDEVTEAYY TTGHYSIFIK VMCRSIDALQ 120
HVLINKIQTI DEIQSTETLI VLQNPIMRTI KP 152 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0016597; F:amino acid binding; IPI:EcoCyc.
 GO:0043565; F:sequence-specific DNA binding; ISS:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0043200; P:response to amino acid stimulus; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000485; AsnC-type_HTH_dom.
 IPR011008; Dimeric_a/b-barrel.
 IPR019888; Tscrpt_reg_AsnC-typ.
 IPR019887; Tscrpt_reg_AsnC-typ_C.
 IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01037; AsnC_trans_reg
 PF13404; HTH_AsnC-type 
SMART
 SM00344; HTH_ASNC 
PROSITE
 PS00519; HTH_ASNC_1
 PS50956; HTH_ASNC_2 
PRINTS
 PR00033; HTHASNC.