UniProt Accession

 ITA9_HUMAN; Q13797; Q14638 

Genbank Protein ID

 D25303; AC092055; AC093415; AP006240; L24158 

Genbank Nucleotide ID

 BAA04984.1; AAA16099.1 

Protein Name

 Integrin alpha-9 

Protein Synonyms/Alias

 Integrin alpha-RLC 

Gene Name

 ITGA9 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	GAPKADSKYSPSVKS	acetylation	[1]
73	GAPKADSKYSPSVKS	ubiquitination	[2]
1033	DSWDWVQKNQ*****	ubiquitination	[3]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin. 

Sequence Annotation

 REPEAT 35 96 FG-GAP 1.
 REPEAT 111 174 FG-GAP 2.
 REPEAT 182 233 FG-GAP 3.
 REPEAT 234 289 FG-GAP 4.
 REPEAT 290 349 FG-GAP 5.
 REPEAT 351 408 FG-GAP 6.
 REPEAT 411 474 FG-GAP 7.
 MOTIF 1005 1009 GFFKR motif.
 CARBOHYD 225 225 N-linked (GlcNAc...).
 CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
 CARBOHYD 493 493 N-linked (GlcNAc...) (Potential).
 CARBOHYD 612 612 N-linked (GlcNAc...) (Potential).
 CARBOHYD 654 654 N-linked (GlcNAc...) (Potential).
 CARBOHYD 658 658 N-linked (GlcNAc...) (Potential).
 CARBOHYD 672 672 N-linked (GlcNAc...) (Potential).
 CARBOHYD 676 676 N-linked (GlcNAc...) (Potential).
 CARBOHYD 807 807 N-linked (GlcNAc...) (Potential).
 CARBOHYD 854 854 N-linked (GlcNAc...) (Potential).
 CARBOHYD 904 904 N-linked (GlcNAc...) (Potential).
 DISULFID 87 97 By similarity.
 DISULFID 142 162 By similarity.
 DISULFID 179 194 By similarity.
 DISULFID 482 491 By similarity.
 DISULFID 497 555 By similarity.
 DISULFID 620 625 By similarity.
 DISULFID 696 706 By similarity.
 DISULFID 855 891 By similarity.
 DISULFID 898 903 By similarity.  

Keyword

 Calcium; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Integrin; Membrane; Metal-binding; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1035 AA 

Protein Sequence

Gene Ontology

 GO:0009925; C:basal plasma membrane; IEA:Compara.
 GO:0008305; C:integrin complex; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007155; P:cell adhesion; IGI:MGI.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0030593; P:neutrophil chemotaxis; IEA:Compara. 

Interpro

 IPR013517; FG-GAP.
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS. 

Pfam

 PF01839; FG-GAP
 PF08441; Integrin_alpha2 

SMART

 SM00191; Int_alpha 

PROSITE

 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA 

PRINTS

 PR01185; INTEGRINA.