CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020821
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sedoheptulokinase 
Protein Synonyms/Alias
 SHK; Carbohydrate kinase-like protein 
Gene Name
 Shpk 
Gene Synonyms/Alias
 Carkl 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
360IQAAAQQKDTHLTITubiquitination[1]
439LSRNEVLKQEVQRAFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts as a modulator of macrophage activation through control of glucose metabolism. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
MASRPVTLGI DLGTTSVKAA LLEAAPSLPS GFVVLASCAR AARAETESAV AGPQGREQDV 60
TRIIQALNEC LDALPRQQLQ RVRGIGVSGQ MHGILFWKAG QGCEWMEGGP AFVFEPRAVS 120
HLVTWQDGRC NSSFLASLPK PDSHLSVATG FGCATIFWLL KNSPEFLKSY DAAGTIQDYV 180
VAMLCGLPRP LMSDQNAASW GYFNTQSQSW NLDTLEKAGF PIHLLPDIAE PGSMAGRTSH 240
TWFEIPKGTQ VGIALGDLQA SVYSCMGQRT DAVLNISTSV QLAASMPVGF QPLQTPDPAA 300
PVAFFPYFDR TYLGVAASLN GGNVLATFVH MLVQWMADLG LEVEESTVYS RMIQAAAQQK 360
DTHLTITPTV LGERHLPDQL ASVTRISSSD LSLGHVTRAL CRGIVQNLHS MLPFQQLKEW 420
GVARVVGSGS ALSRNEVLKQ EVQRAFPFPV CFGQDVDAAF GAALVMLQRD LSQKEP 476 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050277; F:sedoheptulokinase activity; IDA:UniProtKB.
 GO:0035963; P:cellular response to interleukin-13; IDA:UniProtKB.
 GO:0071353; P:cellular response to interleukin-4; IDA:UniProtKB.
 GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB.
 GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IDA:UniProtKB.
 GO:0050727; P:regulation of inflammatory response; IDA:UniProtKB.
 GO:0043030; P:regulation of macrophage activation; IDA:UniProtKB. 
Interpro
 IPR018484; Carb_kinase_FGGY_N. 
Pfam
 PF00370; FGGY_N 
SMART
  
PROSITE
 PS00933; FGGY_KINASES_1
 PS00445; FGGY_KINASES_2 
PRINTS