UniProt Accession

 LCMT1_HUMAN; Q9UIC8; A6NL89; A8K770; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9Y378 

Genbank Protein ID

 AF037601; AF151826; AK025884; AK223364; AK291885; AK314409; AC008741; AC133552; BC001214; BC014217; AL137283 

Genbank Nucleotide ID

 AAF18267.1; AAD34063.1; BAB15270.1; BAD97084.1; BAF84574.1; BAG37031.1; AAH01214.1; AAH14217.1; CAB70677.1 

Protein Name

 Leucine carboxyl methyltransferase 1 

Protein Synonyms/Alias

 Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 

Gene Name

 LCMT1 

Gene Synonyms/Alias

 LCMT; CGI-68 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
181	DLSELEEKLKKCNMN	acetylation	[1]
330	GGNELGLKEITY***	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. 

Sequence Annotation

 REGION 171 172 S-adenosyl-L-methionine binding.
 BINDING 73 73 S-adenosyl-L-methionine.
 BINDING 98 98 S-adenosyl-L-methionine; via carbonyl
 BINDING 122 122 S-adenosyl-L-methionine.
 BINDING 198 198 S-adenosyl-L-methionine; via carbonyl  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0003880; F:protein C-terminal carboxyl O-methyltransferase activity; IDA:MGI.
 GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; TAS:ProtInc.
 GO:0031333; P:negative regulation of protein complex assembly; IMP:MGI.
 GO:0042981; P:regulation of apoptotic process; IMP:MGI.
 GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; IMP:MGI. 

Interpro

 IPR007213; LCM_MeTrfase.
 IPR021121; LCM_MeTrfase_euk.
 IPR016651; Leu_CO_MeTrfase_LCTM1. 

Pfam

 PF04072; LCM 

SMART

  

PROSITE

  

PRINTS