CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040089
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integrin-linked protein kinase 
Protein Synonyms/Alias
  
Gene Name
 Ilk 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
107KHSGIDFKQLNFLAKacetylation[1]
107KHSGIDFKQLNFLAKubiquitination[2]
125NHSGELWKGRWQGNDubiquitination[2]
136QGNDIVVKVLKVRDWacetylation[3, 4]
136QGNDIVVKVLKVRDWubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 218 AA 
Protein Sequence
XLLQYKADIN AVNEHGNVPL HYACFWGQDQ VAEDLVANGA LVSICNKYGE MPVDKAKAPL 60
RELLRERAEK MGQNLNRIPY KDTFWKGTTR TRPRNGTLNK HSGIDFKQLN FLAKLNENHS 120
GELWKGRWQG NDIVVKVLKV RDWSTRKSRD FNEECPRLRW DTELEAVVSK APQVVLKNFV 180
VDQSQAVKFA LDMARGMAFL HTLEPLIPRH ALNSRSVM 218 
Gene Ontology
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0004674; F:protein serine/threonine kinase activity; ISO:MGI.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:MGI.
 GO:0030030; P:cell projection organization; IMP:MGI.
 GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IMP:MGI.
 GO:0007229; P:integrin-mediated signaling pathway; ISO:MGI.
 GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.
 GO:0021675; P:nerve development; IMP:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0043491; P:protein kinase B signaling cascade; IMP:MGI. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
  
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS