CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037464
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 HEAT repeat-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 HEATR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
80SYLETVTKDILAPNLubiquitination[1, 2, 3]
140TTLEEDSKMTRLISCubiquitination[1, 4, 5]
155RIINTFLKTSGGMTDubiquitination[1, 2, 3]
165GGMTDPEKLIRIYPEubiquitination[1, 2]
175RIYPELLKRLDDVSNubiquitination[2, 3]
200VTWLQCVKGANAKSYubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 280 AA 
Protein Sequence
MTGGAREKAH IARSPATAQG PALGEALPHV VPTLRACLQP SQDPQMRLKL FSILSTVLLR 60
ATDTINSQGQ FPSYLETVTK DILAPNLQWH AGRTAAAIRT AAVSCLWALT SSEVLSAEQI 120
RDVQETLMPQ VLTTLEEDSK MTRLISCRII NTFLKTSGGM TDPEKLIRIY PELLKRLDDV 180
SNDVRMAAAS TLVTWLQCVK GANAKSYYQS SVQYLYRELL VHLDDPERAI QDAILEVLKE 240
GSGLFPDLLV RETEAVIHKH RSATYCEQLL QHVQAVPATQ 280 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT.
 IPR021133; HEAT_type_2. 
Pfam
 PF02985; HEAT 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS