CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005576
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-2 complex subunit beta 
Protein Synonyms/Alias
 Beta-2-adaptin; Beta-adaptin; Clathrin assembly protein complex 2 beta large chain; Clathrin assembly protein large beta chain 
Gene Name
 APL1 
Gene Synonyms/Alias
 YAP80; YJR005W; J1422 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
87IRVIGALKPQQAREAubiquitination[1]
660AMMDDYDKPAEKINQubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor. 
Sequence Annotation
 MOD_RES 649 649 Phosphoserine.
 MOD_RES 652 652 Phosphothreonine.
 MOD_RES 683 683 Phosphoserine.  
Keyword
 Cell membrane; Coated pit; Complete proteome; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 700 AA 
Protein Sequence
MSDQKVFARY KANEIVTDLQ HFGVKKFKSN ITRRKNALRK IIANLVLGNY GEMSVLFSEL 60
LKFWQIEDDL EVKRICHEYI RVIGALKPQQ AREALPFIMD DFKSRDEKLQ IMALRTLVLV 120
PVKELSDQAF DCIISLVNHK SPPEQVTRTA IYALLDLDEI DHERVLGLSS ILHDIVKAQS 180
SSPEVIVAAL HTLYSIHEKN ANMEPFRIPL ELAFDMLELL PELNEWNKAT VLEVLTTSVV 240
PQHYLDTHEM IELALPYLQQ VNTYVVLNSL KFIMYLLNYV DVIKETLAEK LSNSVIALLD 300
KPPELQFLVL RNVILLLLSR ESSLLRLDIS YFFIEYNDPI YIKDTKLECL YLLANKETLP 360
RILEELEQYA TDIDIQMSRK SVRAIGNLAV KLDEDSVHDC VAVLLDLLEF GVDYVVQEII 420
SVFRNILRKY PNNFKANVTE LVKHTEVVQE PESKNAMIWI ITQYSDVIPN YLELFRVFSS 480
NMFSETLEVQ FSILNSAIKF FIRSPTKETE ELCMDLLKGC IDHENNPDLR DKTLMYWRLL 540
SLTKTSRISN AITFESLKSV LDGELPLIEM NTKLDPTVLE ELELNIGTIV SIYLKPVSHI 600
FRLNKTKLLP QSPILNPNKD LLPVVGNSFP PTGANRDRQN SESQSSTKSR KTAMMDDYDK 660
PAEKINQLKG KRKSSSNNPS KLSRKPSTLL RKLSMKRPFS 700 
Gene Ontology
 GO:0030122; C:AP-2 adaptor complex; IDA:SGD.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IC:SGD. 
Interpro
 IPR026739; AP_beta.
 IPR016342; AP_complex_bsu_1_2_4.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR002553; Clathrin/coatomer_adapt-like_N. 
Pfam
 PF01602; Adaptin_N 
SMART
  
PROSITE
  
PRINTS