UniProt Accession

 HVCN1_HUMAN; Q96D96; A8MQ37; B4DEB3; F8WCH5; Q6UW11; Q96IS5 

Genbank Protein ID

 AY359054; AK293543; AC144522; CH471054; CH471054; BC007277; BC009731; BC032672 

Genbank Nucleotide ID

 AAQ89413.1; BAG57024.1; EAW97935.1; EAW97936.1; AAH07277.1; AAH09731.1; AAH32672.1 

Protein Name

 Voltage-gated hydrogen channel 1 

Protein Synonyms/Alias

 Hydrogen voltage-gated channel 1; HV1; Voltage sensor domain-only protein 

Gene Name

 HVCN1 

Gene Synonyms/Alias

 VSOP; UNQ578/PRO1140 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MATWDEKAVTRRAK	ubiquitination	[1]
43	HAWNINYKKWENEEE	ubiquitination	[2, 3]
232	ERQLLRLKQMNVQLA	ubiquitination	[1]
252	LEFSCSEKEQEIERL	acetylation	[4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. 

Sequence Annotation

  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 273 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:HGNC.
 GO:0030171; F:voltage-gated proton channel activity; IDA:HGNC.
 GO:0009268; P:response to pH; ISS:HGNC.
 GO:0010043; P:response to zinc ion; IDA:HGNC. 

Interpro

 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom. 

Pfam

 PF00520; Ion_trans 

SMART

  

PROSITE

  

PRINTS