UniProt Accession

 SENP2_HUMAN; Q9HC62; Q8IW97; Q96SR2; Q9P2L5 

Genbank Protein ID

 AF151697; AB037752; AK027599; BC040609; AL834380 

Genbank Nucleotide ID

 AAG15309.2; BAA92569.2; BAB55222.1; AAH40609.1; CAD39043.1 

Protein Name

 Sentrin-specific protease 2 

Protein Synonyms/Alias

 Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2 

Gene Name

 SENP2 

Gene Synonyms/Alias

 KIAA1331 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
271	KTTQFVPKQYRLVET	acetylation	[1]
271	KTTQFVPKQYRLVET	ubiquitination	[2]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). 

Sequence Annotation

 REGION 396 560 Protease.
 MOTIF 28 31 Nuclear localization signal.
 MOTIF 46 51 Nuclear localization signal.
 MOTIF 317 332 Nuclear export signal.
 ACT_SITE 478 478
 ACT_SITE 495 495
 ACT_SITE 548 548 Nucleophile.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Polymorphism; Protease; Protein transport; Reference proteome; Thiol protease; Translocation; Transport; Ubl conjugation; Ubl conjugation pathway; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 589 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005643; C:nuclear pore; IDA:UniProtKB.
 GO:0016605; C:PML body; IEA:Compara.
 GO:0016929; F:SUMO-specific protease activity; IDA:UniProtKB.
 GO:0009950; P:dorsal/ventral axis specification; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0035562; P:negative regulation of chromatin binding; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0016926; P:protein desumoylation; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0030111; P:regulation of Wnt receptor signaling pathway; NAS:UniProtKB.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR003653; Peptidase_C48. 

Pfam

 PF02902; Peptidase_C48 

SMART

  

PROSITE

 PS50600; ULP_PROTEASE 

PRINTS