UniProt Accession

 PRPS2_RAT; P09330; Q63462 

Genbank Protein ID

 M17259; M29393; X16555 

Genbank Nucleotide ID

 AAA41964.1; AAA41961.1; CAA34556.1 

Protein Name

 Ribose-phosphate pyrophosphokinase 2 

Protein Synonyms/Alias

 Phosphoribosyl pyrophosphate synthase II; PRS-II 

Gene Name

 Prps2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
29	RLGLELGKVVTKKFS	ubiquitination	[1]
212	MVLVGDVKDRVAILV	ubiquitination	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. 

Sequence Annotation

 NP_BIND 96 101 ATP (By similarity).
 REGION 212 227 Binding of phosphoribosylpyrophosphate
 METAL 128 128 Magnesium (Potential).
 METAL 130 130 Magnesium (Potential).
 METAL 139 139 Magnesium (Potential).
 METAL 143 143 Magnesium (Potential).
 BINDING 130 130 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0002189; C:ribose phosphate diphosphokinase complex; IDA:RGD.
 GO:0043531; F:ADP binding; IDA:RGD.
 GO:0016208; F:AMP binding; IDA:RGD.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0030246; F:carbohydrate binding; IDA:RGD.
 GO:0019003; F:GDP binding; IDA:RGD.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0004749; F:ribose phosphate diphosphokinase activity; ISS:UniProtKB.
 GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IDA:RGD.
 GO:0006167; P:AMP biosynthetic process; IDA:RGD.
 GO:0031100; P:organ regeneration; IEP:RGD. 

Interpro

 IPR000842; PRib_PP_synth_CS.
 IPR000836; PRibTrfase_dom.
 IPR005946; Rib-P_diPkinase. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00114; PRPP_SYNTHASE 

PRINTS