CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012998
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein tweety homolog 2 
Protein Synonyms/Alias
 mTTY2 
Gene Name
 Ttyh2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
147SANTQRMKVDLEQHLubiquitination[1]
415CAGPRAWKYFINRDRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation (By similarity). 
Sequence Annotation
 MOD_RES 199 199 Phosphothreonine (By similarity).
 CARBOHYD 283 283 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calcium; Cell membrane; Chloride; Chloride channel; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 532 AA 
Protein Sequence
MPAARVEYIA PWWVVWLHSV PHLGLRLQRV DSTFSPGDET YQESLLFLGV LAAIGLGLNL 60
IFLTVYLVCT CCCRRDHTVQ TKQQESCCVT WTAVVAGLLC CAAVGVGFYG NSETNDGMHQ 120
LIYSLDNANH TFSGMDELVS ANTQRMKVDL EQHLARLSEI IAARGDYIQT LKFMQQMAGN 180
VVSQLSGLPV WREVTTQLTK LSHQTAYVEY YRWLSYLLLF ILDLVICLVT CLGLARRSKC 240
LLASMLCCGI LTLILSWASL AADAAAAVGT SDFCMAPDIY ILNNTGSQIN SEVTRYYLHC 300
SQSLISPFQQ SLTTFQRSLT TMQIQVGGLL QFAVPLFPTA EKDLLGIQLL LNNSEISLHQ 360
LTAMLDCRGL HKDYLDALTG ICYDGIEGLL FLGLFSLLAA LAFSTLTCAG PRAWKYFINR 420
DRDYDDIDDD DPFNPQARRI AAHNPTRGQL HSFCSYSSGL GSQCSLQPPS QTISNAPVSE 480
YMNQAILFGG NPRYENVPLI GRGSPPPTYS PSMRPTYMSV ADEHLRHYEF PS 532 
Gene Ontology
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; ISS:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW. 
Interpro
 IPR006990; Tweety. 
Pfam
 PF04906; Tweety 
SMART
  
PROSITE
  
PRINTS