CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032139
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol transfer protein beta isoform 
Protein Synonyms/Alias
 Phosphatidylinositol transfer protein, beta, isoform CRA_a; cDNA FLJ53628, highly similar to Phosphatidylinositol transfer protein beta isoform 
Gene Name
 PITPNB 
Gene Synonyms/Alias
 hCG_41089 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
181PLGPNWKKELANSPDubiquitination[1, 2, 3, 4]
203KLVTIKFKWWGLQSKubiquitination[1, 3, 5]
210KWWGLQSKVENFIQKubiquitination[1, 6, 7]
217KVENFIQKQEKRIFTubiquitination[1, 5, 6]
220NFIQKQEKRIFTNFHubiquitination[3]
254RMEDETQKELETMRKubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 273 AA 
Protein Sequence
MGDLLMEKCR VVLPCSVQEY QVGQLYSVAE ASKNETGGGE GIEVLKNEPY EKDGEKGQYT 60
HKIYHLKSKV PAFVRMIAPE GSLVFHEKAW NAYPYCRTIV TNEYMKDDFF IKIETWHKPD 120
LGTLENVHGL DPNTWKTVEI VHIDIADRSQ VEPADYKADE DPALFQSVKT KRGPLGPNWK 180
KELANSPDCP QMCAYKLVTI KFKWWGLQSK VENFIQKQEK RIFTNFHRQL FCWIDKWIDL 240
TMEDIRRMED ETQKELETMR KRGSVRGTSA ADV 273 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0006810; P:transport; IEA:InterPro. 
Interpro
 IPR001666; PI_transfer.
 IPR023393; START-like_dom. 
Pfam
 PF02121; IP_trans 
SMART
  
PROSITE
  
PRINTS
 PR00391; PITRANSFER.