UniProt Accession

 PPIC_MOUSE; P30412 

Genbank Protein ID

 M74227; BC025861 

Genbank Nucleotide ID

 AAA37511.1; AAH25861.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase C 

Protein Synonyms/Alias

 PPIase C; Cyclophilin C; Rotamase C 

Gene Name

 Ppic 

Gene Synonyms/Alias

 Cypc 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	RGPSVTDKVFFDVRI	acetylation	[1]
49	FDVRIGDKDVGRIVI	acetylation	[2]
92	SIFHRVIKDFMIQGG	acetylation	[1]
159	KPTWLDGKHVVFGKV	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 

Sequence Annotation

 DOMAIN 41 198 PPIase cyclophilin-type.  

Keyword

 3D-structure; Complete proteome; Cyclosporin; Cytoplasm; Isomerase; Reference proteome; Rotamase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0042277; F:peptide binding; IEA:UniProtKB-KW.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR024936; Cyclophilin-type_PPIase.
 IPR020892; Cyclophilin-type_PPIase_CS. 

Pfam

 PF00160; Pro_isomerase 

SMART

  

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 

PRINTS

 PR00153; CSAPPISMRASE.