UniProt Accession

 VDAC3_MOUSE; Q60931; Q8BNG2 

Genbank Protein ID

 U30839; AK083785; BC004743 

Genbank Nucleotide ID

 AAB47776.1; BAC39019.1; AAH04743.1 

Protein Name

 Voltage-dependent anion-selective channel protein 3 

Protein Synonyms/Alias

 VDAC-3; mVDAC3; Outer mitochondrial membrane protein porin 3 

Gene Name

 Vdac3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
15	CDLGKAAKDVFNKGY	acetylation	[1]
20	AAKDVFNKGYGFGMV	acetylation	[1, 2, 3]
28	GYGFGMVKIDLKTKS	acetylation	[1]
61	ASGNLETKYKVCNYG	acetylation	[1, 2, 3]
63	GNLETKYKVCNYGLT	acetylation	[1]
163	SFDTAKSKLSQNNFA	acetylation	[1]
224	TRFGIAAKYKLDCRT	acetylation	[1]
226	FGIAAKYKLDCRTSL	acetylation	[1, 2, 3]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [3] Proteomics of mitochondrial inner and outer membranes.
 Distler AM, Kerner J, Hoppel CL.
 Proteomics. 2008 Oct;8(19):4066-82. [PMID: 18763707] 

Functional Description

 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). 

Sequence Annotation

 NP_BIND 242 244 NAD (By similarity).
 NP_BIND 260 264 NAD (By similarity).
 MOD_RES 2 2 N-acetylcysteine (By similarity).
 MOD_RES 20 20 N6-acetyllysine.
 MOD_RES 48 48 Phosphotyrosine.
 MOD_RES 61 61 N6-acetyllysine.
 MOD_RES 90 90 N6-acetyllysine (By similarity).
 MOD_RES 226 226 N6-acetyllysine.
 MOD_RES 241 241 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Nucleotide-binding; Phosphoprotein; Porin; Reference proteome; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IEA:UniProtKB-KW.
 GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro.
 GO:0001662; P:behavioral fear response; IMP:MGI.
 GO:0007612; P:learning; IMP:MGI.
 GO:0007270; P:neuron-neuron synaptic transmission; IMP:MGI. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

 PS00558; EUKARYOTIC_PORIN 

PRINTS

 PR00185; EUKARYTPORIN.