UniProt Accession

 GPR39_MOUSE; Q5U431; Q80UC7 

Genbank Protein ID

 BC085285; AY255549 

Genbank Nucleotide ID

 AAH85285.1; AAO85061.1 

Protein Name

 G-protein coupled receptor 39 

Protein Synonyms/Alias

  

Gene Name

 Gpr39 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
253	MKVLMKSKQGTLAGT	ubiquitination	[1]
382	RARFISTKDSTSSAR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Zn(2+) acts as a agonist (By similarity). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death. 

Sequence Annotation

 METAL 17 17 Zinc (By similarity).
 METAL 19 19 Zinc (By similarity).
 MOD_RES 380 380 Phosphoserine.
 CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
 DISULFID 11 191 By similarity.
 DISULFID 108 210 By similarity.  

Keyword

 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 456 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008343; P:adult feeding behavior; IMP:MGI.
 GO:0071294; P:cellular response to zinc ion; IMP:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0002024; P:diet induced thermogenesis; IMP:MGI.
 GO:0035483; P:gastric emptying; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0060455; P:negative regulation of gastric acid secretion; IMP:MGI.
 GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:MGI.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IMP:MGI.
 GO:0019216; P:regulation of lipid metabolic process; IMP:MGI.
 GO:0042391; P:regulation of membrane potential; IMP:MGI. 

Interpro

 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00237; GPCRRHODOPSN.