UniProt Accession

 PGFRB_HUMAN; P09619; Q8N5L4 

Genbank Protein ID

 J03278; M21616; AC005895; AC011382; BC032224; U33172 

Genbank Nucleotide ID

 AAA60049.1; AAA36427.1; AAH32224.1; AAC51675.1 

Protein Name

 Platelet-derived growth factor receptor beta 

Protein Synonyms/Alias

 PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD140b 

Gene Name

 PDGFRB 

Gene Synonyms/Alias

 PDGFR; PDGFR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
707	FLQHHSDKRRPPSAE	ubiquitination	[1, 2]

Reference

 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. 

Sequence Annotation

 DOMAIN 33 120 Ig-like C2-type 1.
 DOMAIN 129 210 Ig-like C2-type 2.
 DOMAIN 214 309 Ig-like C2-type 3.
 DOMAIN 331 403 Ig-like C2-type 4.
 DOMAIN 416 524 Ig-like C2-type 5.
 DOMAIN 600 962 Protein kinase.
 NP_BIND 606 614 ATP (By similarity).
 ACT_SITE 826 826 Proton acceptor (By similarity).
 BINDING 634 634 ATP (Probable).
 MOD_RES 562 562 Phosphotyrosine; by autocatalysis.
 MOD_RES 579 579 Phosphotyrosine; by autocatalysis.
 MOD_RES 581 581 Phosphotyrosine; by autocatalysis.
 MOD_RES 589 589 Phosphotyrosine; by autocatalysis.
 MOD_RES 686 686 Phosphotyrosine; by ABL1 and ABL2 (By
 MOD_RES 716 716 Phosphotyrosine; by autocatalysis.
 MOD_RES 740 740 Phosphotyrosine; by autocatalysis.
 MOD_RES 751 751 Phosphotyrosine; by autocatalysis.
 MOD_RES 763 763 Phosphotyrosine; by autocatalysis.
 MOD_RES 771 771 Phosphotyrosine; by autocatalysis.
 MOD_RES 775 775 Phosphotyrosine; by autocatalysis.
 MOD_RES 778 778 Phosphotyrosine; by autocatalysis.
 MOD_RES 857 857 Phosphotyrosine; by autocatalysis.
 MOD_RES 934 934 Phosphotyrosine; by ABL1 and ABL2 (By
 MOD_RES 970 970 Phosphotyrosine; by ABL1 and ABL2 (By
 MOD_RES 1009 1009 Phosphotyrosine; by autocatalysis.
 MOD_RES 1021 1021 Phosphotyrosine; by autocatalysis.
 CARBOHYD 45 45 N-linked (GlcNAc...) (Potential).
 CARBOHYD 89 89 N-linked (GlcNAc...).
 CARBOHYD 103 103 N-linked (GlcNAc...).
 CARBOHYD 215 215 N-linked (GlcNAc...).
 CARBOHYD 230 230 N-linked (GlcNAc...).
 CARBOHYD 292 292 N-linked (GlcNAc...).
 CARBOHYD 307 307 N-linked (GlcNAc...).
 CARBOHYD 354 354 N-linked (GlcNAc...) (Potential).
 CARBOHYD 371 371 N-linked (GlcNAc...) (Potential).
 CARBOHYD 468 468 N-linked (GlcNAc...) (Potential).
 CARBOHYD 479 479 N-linked (GlcNAc...) (Potential).
 DISULFID 54 100
 DISULFID 149 190
 DISULFID 235 291
 DISULFID 436 508 By similarity.  

Keyword

 3D-structure; ATP-binding; Cell membrane; Chemotaxis; Chromosomal rearrangement; Complete proteome; Cytoplasmic vesicle; Developmental protein; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1106 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0031226; C:intrinsic to plasma membrane; IDA:UniProtKB.
 GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004992; F:platelet activating factor receptor activity; TAS:ProtInc.
 GO:0005019; F:platelet-derived growth factor beta-receptor activity; IDA:UniProtKB.
 GO:0048407; F:platelet-derived growth factor binding; IDA:UniProtKB.
 GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
 GO:0030325; P:adrenal gland development; IEA:Compara.
 GO:0035909; P:aorta morphogenesis; ISS:BHF-UCL.
 GO:0055003; P:cardiac myofibril assembly; ISS:UniProtKB.
 GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.
 GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0048839; P:inner ear development; IEA:Compara.
 GO:0007243; P:intracellular protein kinase cascade; IEA:Compara.
 GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Compara.
 GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
 GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; ISS:UniProtKB.
 GO:0035789; P:metanephric mesenchymal cell migration; IEA:Compara.
 GO:0072075; P:metanephric mesenchyme development; IEA:Compara.
 GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Compara.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
 GO:0046488; P:phosphatidylinositol metabolic process; IMP:UniProtKB.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IMP:UniProtKB.
 GO:0090280; P:positive regulation of calcium ion import; ISS:UniProtKB.
 GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
 GO:0050921; P:positive regulation of chemotaxis; ISS:UniProtKB.
 GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Compara.
 GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
 GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
 GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISS:UniProtKB.
 GO:0045840; P:positive regulation of mitosis; ISS:UniProtKB.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:UniProtKB.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:UniProtKB.
 GO:0010863; P:positive regulation of phospholipase C activity; IDA:UniProtKB.
 GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
 GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.
 GO:0032956; P:regulation of actin cytoskeleton organization; ISS:BHF-UCL.
 GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0034405; P:response to fluid shear stress; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0055093; P:response to hyperoxia; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.
 GO:0048705; P:skeletal system morphogenesis; IEA:Compara.
 GO:0071670; P:smooth muscle cell chemotaxis; ISS:BHF-UCL.
 GO:0048745; P:smooth muscle tissue development; IEA:Compara.
 GO:0001894; P:tissue homeostasis; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro.
 GO:0042060; P:wound healing; IEA:Compara. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013151; Immunoglobulin.
 IPR011009; Kinase-like_dom.
 IPR027288; PGFRB.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
 IPR001824; Tyr_kinase_rcpt_3_CS.
 IPR009134; Tyr_kinase_VEGFR_rcpt_N. 

Pfam

 PF07679; I-set
 PF00047; ig
 PF07714; Pkinase_Tyr 

SMART

 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 

PROSITE

 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00240; RECEPTOR_TYR_KIN_III 

PRINTS

 PR01832; VEGFRECEPTOR.