UniProt Accession

 RBPMS_HUMAN; Q93062; D3DSU9; Q92516; Q92517; Q92518; Q96J26 

Genbank Protein ID

 D84110; D84107; D84108; D84109; D84111; CH471080; CH471080; BC003608 

Genbank Nucleotide ID

 BAA12228.1; BAA12225.1; BAA12226.1; BAA12227.1; BAA12229.1; EAW63451.1; EAW63453.1; AAH03608.1 

Protein Name

 RNA-binding protein with multiple splicing 

Protein Synonyms/Alias

 RBP-MS; Heart and RRM expressed sequence; Hermes 

Gene Name

 RBPMS 

Gene Synonyms/Alias

 HERMES 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	SGLPLDIKPRELYLL	ubiquitination	[1]
60	SLIKLTSKQPVGFVS	ubiquitination	[1]
109	NTKMAKNKLVGTPNP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. 

Sequence Annotation

 DOMAIN 24 101 RRM.
 MOD_RES 113 113 Phosphothreonine.  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008143; F:poly(A) RNA binding; IDA:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:UniProtKB.
 GO:0060391; P:positive regulation of SMAD protein import into nucleus; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006396; P:RNA processing; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS