| Tag | Content |
|---|
| CPLM ID | CPLM-014352 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Fibrillin-2 |
Protein Synonyms/Alias | |
Gene Name | Fbn2 |
Gene Synonyms/Alias | Fbn-2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1012 | CIHPVPGKFRMDACC | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. |
Sequence Annotation | DOMAIN 111 142 EGF-like 1.
DOMAIN 145 176 EGF-like 2.
DOMAIN 176 208 EGF-like 3.
DOMAIN 214 266 TB 1.
DOMAIN 276 317 EGF-like 4; calcium-binding.
DOMAIN 318 359 EGF-like 5; calcium-binding.
DOMAIN 364 417 TB 2.
DOMAIN 487 527 EGF-like 6.
DOMAIN 528 567 EGF-like 7; calcium-binding.
DOMAIN 568 609 EGF-like 8; calcium-binding.
DOMAIN 610 650 EGF-like 9; calcium-binding.
DOMAIN 651 691 EGF-like 10; calcium-binding.
DOMAIN 697 749 TB 3.
DOMAIN 761 802 EGF-like 11; calcium-binding.
DOMAIN 803 844 EGF-like 12; calcium-binding.
DOMAIN 845 883 EGF-like 13; calcium-binding.
DOMAIN 889 940 TB 4.
DOMAIN 948 989 EGF-like 14; calcium-binding.
DOMAIN 994 1045 TB 5.
DOMAIN 1066 1107 EGF-like 15; calcium-binding.
DOMAIN 1108 1150 EGF-like 16; calcium-binding.
DOMAIN 1151 1192 EGF-like 17; calcium-binding.
DOMAIN 1193 1234 EGF-like 18; calcium-binding.
DOMAIN 1235 1275 EGF-like 19; calcium-binding.
DOMAIN 1276 1317 EGF-like 20; calcium-binding.
DOMAIN 1318 1359 EGF-like 21; calcium-binding.
DOMAIN 1360 1400 EGF-like 22; calcium-binding.
DOMAIN 1401 1441 EGF-like 23; calcium-binding.
DOMAIN 1442 1483 EGF-like 24; calcium-binding.
DOMAIN 1484 1524 EGF-like 25; calcium-binding.
DOMAIN 1525 1565 EGF-like 26; calcium-binding.
DOMAIN 1570 1626 TB 6.
DOMAIN 1643 1684 EGF-like 27; calcium-binding.
DOMAIN 1685 1726 EGF-like 28; calcium-binding.
DOMAIN 1731 1784 TB 7.
DOMAIN 1801 1842 EGF-like 29; calcium-binding.
DOMAIN 1843 1884 EGF-like 30; calcium-binding.
DOMAIN 1885 1926 EGF-like 31; calcium-binding.
DOMAIN 1927 1965 EGF-like 32; calcium-binding.
DOMAIN 1966 2008 EGF-like 33; calcium-binding.
DOMAIN 2009 2048 EGF-like 34; calcium-binding.
DOMAIN 2049 2090 EGF-like 35; calcium-binding.
DOMAIN 2095 2148 TB 8.
DOMAIN 2164 2205 EGF-like 36; calcium-binding.
DOMAIN 2206 2245 EGF-like 37; calcium-binding.
DOMAIN 2246 2286 EGF-like 38; calcium-binding.
DOMAIN 2287 2330 EGF-like 39; calcium-binding.
DOMAIN 2331 2372 EGF-like 40; calcium-binding.
DOMAIN 2377 2430 TB 9.
DOMAIN 2442 2483 EGF-like 41; calcium-binding.
DOMAIN 2484 2524 EGF-like 42; calcium-binding.
DOMAIN 2525 2563 EGF-like 43; calcium-binding.
DOMAIN 2564 2606 EGF-like 44; calcium-binding.
DOMAIN 2607 2646 EGF-like 45; calcium-binding.
DOMAIN 2647 2687 EGF-like 46; calcium-binding.
DOMAIN 2688 2727 EGF-like 47; calcium-binding.
CARBOHYD 485 485 N-linked (GlcNAc...) (Potential).
CARBOHYD 1105 1105 N-linked (GlcNAc...) (Potential).
CARBOHYD 1407 1407 N-linked (GlcNAc...) (Potential).
CARBOHYD 1522 1522 N-linked (GlcNAc...) (Potential).
CARBOHYD 1558 1558 N-linked (GlcNAc...) (Potential).
CARBOHYD 1618 1618 N-linked (GlcNAc...) (Potential).
CARBOHYD 1707 1707 N-linked (GlcNAc...) (Potential).
CARBOHYD 1738 1738 N-linked (GlcNAc...) (Potential).
CARBOHYD 1749 1749 N-linked (GlcNAc...) (Potential).
CARBOHYD 1938 1938 N-linked (GlcNAc...) (Potential).
CARBOHYD 2113 2113 N-linked (GlcNAc...) (Potential).
CARBOHYD 2218 2218 N-linked (GlcNAc...) (Potential).
CARBOHYD 2803 2803 N-linked (GlcNAc...) (Potential).
DISULFID 115 124 By similarity.
DISULFID 119 130 By similarity.
DISULFID 132 141 By similarity.
DISULFID 149 159 By similarity.
DISULFID 153 164 By similarity.
DISULFID 166 175 By similarity.
DISULFID 180 190 By similarity.
DISULFID 184 196 By similarity.
DISULFID 198 207 By similarity.
DISULFID 280 292 By similarity.
DISULFID 287 301 By similarity.
DISULFID 303 316 By similarity.
DISULFID 322 334 By similarity.
DISULFID 329 343 By similarity.
DISULFID 345 358 By similarity.
DISULFID 491 503 By similarity.
DISULFID 498 512 By similarity.
DISULFID 514 526 By similarity.
DISULFID 532 542 By similarity.
DISULFID 537 551 By similarity.
DISULFID 553 566 By similarity.
DISULFID 572 584 By similarity.
DISULFID 579 593 By similarity.
DISULFID 595 608 By similarity.
DISULFID 614 625 By similarity.
DISULFID 620 634 By similarity.
DISULFID 636 649 By similarity.
DISULFID 655 666 By similarity.
DISULFID 661 675 By similarity.
DISULFID 677 690 By similarity.
DISULFID 765 777 By similarity.
DISULFID 772 786 By similarity.
DISULFID 788 801 By similarity.
DISULFID 807 819 By similarity.
DISULFID 814 828 By similarity.
DISULFID 830 843 By similarity.
DISULFID 849 859 By similarity.
DISULFID 854 868 By similarity.
DISULFID 870 883 By similarity.
DISULFID 952 964 By similarity.
DISULFID 959 973 By similarity.
DISULFID 975 988 By similarity.
DISULFID 1070 1082 By similarity.
DISULFID 1077 1091 By similarity.
DISULFID 1093 1106 By similarity.
DISULFID 1112 1124 By similarity.
DISULFID 1119 1133 By similarity.
DISULFID 1135 1149 By similarity.
DISULFID 1155 1167 By similarity.
DISULFID 1162 1176 By similarity.
DISULFID 1178 1191 By similarity.
DISULFID 1197 1209 By similarity.
DISULFID 1204 1218 By similarity.
DISULFID 1220 1233 By similarity.
DISULFID 1239 1250 By similarity.
DISULFID 1246 1259 By similarity.
DISULFID 1261 1274 By similarity.
DISULFID 1280 1292 By similarity.
DISULFID 1287 1301 By similarity.
DISULFID 1303 1316 By similarity.
DISULFID 1322 1334 By similarity.
DISULFID 1329 1343 By similarity.
DISULFID 1345 1358 By similarity.
DISULFID 1364 1377 By similarity.
DISULFID 1371 1386 By similarity.
DISULFID 1388 1399 By similarity.
DISULFID 1405 1418 By similarity.
DISULFID 1412 1427 By similarity.
DISULFID 1429 1440 By similarity.
DISULFID 1446 1458 By similarity.
DISULFID 1453 1467 By similarity.
DISULFID 1469 1482 By similarity.
DISULFID 1488 1499 By similarity.
DISULFID 1494 1508 By similarity.
DISULFID 1510 1523 By similarity.
DISULFID 1529 1540 By similarity.
DISULFID 1535 1549 By similarity.
DISULFID 1551 1564 By similarity.
DISULFID 1647 1659 By similarity.
DISULFID 1654 1668 By similarity.
DISULFID 1670 1683 By similarity.
DISULFID 1689 1701 By similarity.
DISULFID 1696 1710 By similarity.
DISULFID 1712 1725 By similarity.
DISULFID 1805 1817 By similarity.
DISULFID 1812 1826 By similarity.
DISULFID 1828 1841 By similarity.
DISULFID 1847 1860 By similarity.
DISULFID 1854 1869 By similarity.
DISULFID 1871 1883 By similarity.
DISULFID 1889 1901 By similarity.
DISULFID 1896 1910 By similarity.
DISULFID 1912 1925 By similarity.
DISULFID 1931 1941 By similarity.
DISULFID 1936 1950 By similarity.
DISULFID 1952 1964 By similarity.
DISULFID 1970 1983 By similarity.
DISULFID 1978 1992 By similarity.
DISULFID 1994 2007 By similarity.
DISULFID 2013 2025 By similarity.
DISULFID 2020 2034 By similarity.
DISULFID 2036 2047 By similarity.
DISULFID 2053 2065 By similarity.
DISULFID 2060 2074 By similarity.
DISULFID 2076 2089 By similarity.
DISULFID 2168 2180 By similarity.
DISULFID 2175 2189 By similarity.
DISULFID 2191 2204 By similarity.
DISULFID 2210 2221 By similarity.
DISULFID 2216 2230 By similarity.
DISULFID 2232 2244 By similarity.
DISULFID 2250 2261 By similarity.
DISULFID 2257 2270 By similarity.
DISULFID 2272 2285 By similarity.
DISULFID 2291 2305 By similarity.
DISULFID 2298 2314 By similarity.
DISULFID 2316 2329 By similarity.
DISULFID 2335 2347 By similarity.
DISULFID 2342 2356 By similarity.
DISULFID 2358 2371 By similarity.
DISULFID 2446 2458 By similarity.
DISULFID 2453 2467 By similarity.
DISULFID 2469 2482 By similarity.
DISULFID 2488 2499 By similarity.
DISULFID 2495 2508 By similarity.
DISULFID 2510 2523 By similarity.
DISULFID 2529 2540 By similarity.
DISULFID 2536 2549 By similarity.
DISULFID 2551 2562 By similarity.
DISULFID 2568 2581 By similarity.
DISULFID 2575 2590 By similarity.
DISULFID 2592 2605 By similarity.
DISULFID 2611 2621 By similarity.
DISULFID 2617 2630 By similarity.
DISULFID 2632 2645 By similarity.
DISULFID 2651 2662 By similarity.
DISULFID 2657 2671 By similarity.
DISULFID 2673 2686 By similarity.
DISULFID 2692 2703 By similarity.
DISULFID 2699 2712 By similarity.
DISULFID 2714 2726 By similarity. |
Keyword | Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Extracellular matrix; Glycoprotein; Reference proteome; Repeat; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2907 AA |
Protein Sequence | MGRRRRLCLQ PYFVWLGCVA LWAQGTDGQP QPPPPKTLRP QPPPQQVRPA VAGSEGGFMG 60
PEYRDEGAVA ASRVRRRGQQ EILRGPNVCG SRFHSYCCPG WKTLPGGNQC IVPICRNSCG 120
DGFCSRPNMC TCSSGQISPT CGAKSIQQCS VRCMNGGTCA DDHCQCQKGY IGTYCGQPVC 180
ENGCQNGGRC IGPNRCACVY GFTGPQCERD YRTGPCFTQV NNQMCQGQLT GIVCTKTLCC 240
ATIGRAWGHP CEMCPAQPQP CRRGFIPNIR TGACQDVDEC QAIPGLCQGG NCINTVGSFE 300
CRCPAGHKQS ETTQKCEDID ECSVIPGVCE TGDCSNTVGS YFCLCPRGFV TSTDGSRCID 360
QRAGTCFSGL VNGRCAQELP GRMAKAQCCC EPGRCWSIGT IPEACPVRGS EEYRRLCLDG 420
LPMGGIPGSS VSRPGGTGST GNGYGPGGTG FLPIPGDNGF SPGVGGAGVG AGGQGPIITG 480
LTILNQTIDI CKHHANLCLN GRCIPTVSSY RCECNMGYKQ DANGDCIDVD ECTSNPCSNG 540
DCVNTPGSYY CKCHAGFQRT PTKQACIDID ECIQNGVLCK NGRCVNTDGS FQCICNAGFE 600
LTTDGKNCVD HDECTTTNMC LNGMCINEDG SFKCVCKPGF ILAPNGRYCT DVDECQTPGI 660
CMNGHCINNE GSFRCDCPPG LAVGVDGRVC VDTHMRSTCY GEIKKGVCVR PFPGAVTKSE 720
CCCANPDYGF GEPCQPCPAK NSAEFHGLCS SGIGITVDGR DINECALDPD ICANGICENL 780
RGSYRCNCNS GYEPDASGRN CIDIDECLVN RLLCDNGLCR NTPGSYSCTC PPGYVFRTET 840
ETCEDVNECE SNPCVNGACR NNLGSFHCEC SPGSKLSSTG LICIDSLKGT CWLNIQDNRC 900
EVNINGATLK SECCATLGAA WGSPCERCEL DAACPRGFAR IKGVTCEDVN ECEVFPGVCP 960
NGRCVNSKGS FHCECPEGLT LDGTGRVCLD IRMEHCFLKW DEDECIHPVP GKFRMDACCC 1020
AVGAAWGTEC EECPKPGTKE YETLCPRGPG FANRGDILTG RPFYKDINEC KAFPGMCTYG 1080
KCRNTIGSFK CRCNNGFALD MEERNCTDID ECRISPDLCG SGICVNTPGS FECECFEGYE 1140
SGFMMMKNCM DIDECERNPL LCRGGTCVNT EGSFQCDCPL GHELSPSRED CVDINECSLS 1200
DNLCRNGKCV NMIGTYQCSC NPGYQATPDR QGCTDIDECM IMNGGCDTQC TNSEGSYECS 1260
CSEGYALMPD GRSCADIDEC ENNPDICDGG QCTNIPGEYR CLCYDGFMAS MDMKTCIDVN 1320
ECDLNPNICM FGECENTKGS FICHCQLGYS VKKGTTGCTD VDECEIGAHN CDMHASCLNV 1380
PGSFKCSCRE GWVGNGIKCI DLDECANGTH QCSINAQCVN TPGSYRCACS EGFTGDGFTC 1440
SDVDECAENT NLCENGQCLN VPGAYRCECE MGFTPASDSR SCQDIDECSF QNICVFGTCN 1500
NLPGMFHCIC DDGYELDRTG GNCTDIDECA DPINCVNGLC VNTPGRYECN CPPDFQLNPT 1560
GVGCVDNRVG NCYLKFGPRG DGSLSCNTEV GVGVSRSSCC CSLGKAWGNP CETCPPVNST 1620
EYYTLCPGGE GFRPNPITII LEDIDECQEL PGLCQGGNCI NTFGSFQCEC PQGYYLSEET 1680
RICEDIDECF AHPGVCGPGT CYNTLGNYTC ICPPEYMQVN GGHNCMDMRK SFCYRSYNGT 1740
TCENELPFNV TKRMCCCTYN VGKAWNKPCE PCPTPGTADF KTICGNIPGF TFDIHTGKAV 1800
DIDECKEIPG ICANGVCINQ IGSFRCECPT GFSYNDLLLV CEDIDECSNG DNLCQRNADC 1860
INSPGSYRCE CAAGFKLSPN GACVDRNECL EIPNVCSHGL CVDLQGSYQC ICNNGFKASQ 1920
DQTMCMDVDE CERHPCGNGT CKNTVGSYNC LCYPGFELTH NNDCLDIDEC SSFFGQVCRN 1980
GRCFNEIGSF KCLCNEGYEL TPDGKNCIDT NECVALPGSC SPGTCQNLEG SFRCICPPGY 2040
EVRSENCIDI NECDEDPNIC LFGSCTNTPG GFQCICPPGF VLSDNGRRCF DTRQSFCFTN 2100
FENGKCSVPK AFNTTKAKCC CSKMPGEGWG DPCELCPKDD EVAFQDLCPY GHGTVPSLHD 2160
TREDVNECLE SPGICSNGQC INTDGSFRCE CPMGYNLDYT GVRCVDTDEC SIGNPCGNGT 2220
CTNVIGSFEC TCNEGFEPGP MMNCEDINEC AQNPLLCAFR CMNTFGSYEC TCPVGYALRE 2280
DQKMCKDLDE CAEGLHDCES RGMMCKNLIG TFMCICPPGM ARRPDGEGCV DENECRTKPG 2340
ICENGRCVNI IGSYRCECNE GFQSSSSGTE CLDNRQGLCF AEVLQTMCQM ASSSRNLVTK 2400
SECCCDGGRG WGHQCELCPL PGTAQYKKIC PHGPGYATDG RDIDECKVMP SLCTNGQCVN 2460
TMGSFRCFCK VGYTTDISGT ACVDLDECSQ SPKPCNFICK NTKGSYQCSC PRGYVLQEDG 2520
KTCKDLDECQ TKQHNCQFLC VNTLGGFTCK CPPGFTQHHT ACIDNNECGS QPSLCGAKGI 2580
CQNTPGSFSC ECQRGFSLDA SGLNCEDVDE CDGNHRCQHG CQNILGGYRC GCPQGYVQHY 2640
QWNQCVDENE CSNPGACGSA SCYNTLGSYK CACPSGFSFD QFSSACHDVN ECSSSKNPCS 2700
YGCSNTEGGY LCGCPPGYFR VGQGHCVSGM GFNKGQYLSV DAEAEDDENA LSPEACYECK 2760
INGYTKKDGR RKRSAQEPEP ASAEEQISLE SVAMDSPVNM KFNLSGLGSK EHILELVPAI 2820
EPLNNHIRYV ISQGNEDGVF RIHQRNGLSY LHTAKKKLAP GTYTLEITSI PLYGKKELRK 2880
LEEHNEDDYL LGVLGEALRM RLQIQLY 2907 |
Gene Ontology | GO:0001527; C:microfibril; TAS:BHF-UCL. GO:0005509; F:calcium ion binding; TAS:MGI. GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro. GO:0060346; P:bone trabecula formation; IMP:BHF-UCL. GO:0030326; P:embryonic limb morphogenesis; IMP:MGI. GO:0030501; P:positive regulation of bone mineralization; IMP:BHF-UCL. GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL. GO:0035583; P:sequestering of TGFbeta in extracellular matrix; IMP:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |