UniProt Accession

 F5H2R5_HUMAN; F5H2R5 

Genbank Protein ID

 AC007655 

Genbank Nucleotide ID

  

Protein Name

 Rho GDP-dissociation inhibitor 2 

Protein Synonyms/Alias

  

Gene Name

 ARHGDIB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	DDDELDSKLNYKPPP	acetylation	[1]
21	DDDELDSKLNYKPPP	ubiquitination	[1, 2, 3]
25	LDSKLNYKPPPQKSL	acetylation	[1]
25	LDSKLNYKPPPQKSL	ubiquitination	[1, 2, 3]
30	NYKPPPQKSLKELQE	acetylation	[1]
30	NYKPPPQKSLKELQE	ubiquitination	[1, 3]
33	PPPQKSLKELQEMDK	acetylation	[1]
33	PPPQKSLKELQEMDK	ubiquitination	[1, 2, 3]
40	KELQEMDKDDESLIK	ubiquitination	[3]
47	KDDESLIKYKKTLLG	ubiquitination	[1, 3]
49	DESLIKYKKTLLGDG	ubiquitination	[1, 3]
50	ESLIKYKKTLLGDGP	ubiquitination	[1, 2, 3, 4]
63	GPVVTDPKAPNVVVT	acetylation	[1]
63	GPVVTDPKAPNVVVT	ubiquitination	[1, 2, 3]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 88 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005094; F:Rho GDP-dissociation inhibitor activity; IEA:InterPro. 

Interpro

 IPR014756; Ig_E-set.
 IPR000406; Rho_GDI.
 IPR024792; RhoGDI_domain. 

Pfam

 PF02115; Rho_GDI 

SMART

  

PROSITE

  

PRINTS

 PR00492; RHOGDI.