CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011817
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein MAM3 
Protein Synonyms/Alias
  
Gene Name
 MAM3 
Gene Synonyms/Alias
 YOL060C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
407QQPGPLSKRHITSYLubiquitination[1]
573TQVTTSTKTTRNSPDubiquitination[1]
636AKDWDESKSEYGNENubiquitination[1]
673SSIKNKFKNENANNNubiquitination[1]
705NGSSSTIKR******ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Involved in metal homeostasis and more specially in manganese sensitivity. 
Sequence Annotation
 DOMAIN 65 233 DUF21.
 DOMAIN 259 320 CBS 1.
 DOMAIN 321 386 CBS 2.
 MOD_RES 439 439 Phosphoserine.
 MOD_RES 447 447 Phosphoserine.
 MOD_RES 527 527 Phosphoserine.
 MOD_RES 603 603 Phosphoserine.
 MOD_RES 604 604 Phosphotyrosine.
 MOD_RES 607 607 Phosphothreonine.
 MOD_RES 614 614 Phosphoserine.  
Keyword
 Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Vacuole. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MSFLPLRSRS RSGAPHWVYI ILYHIFTIPK IYSLPLLSGS HVLNSRDVAD SGHSVGDEAS 60
VTTYYIISII LVLLGGVFAG LTLGLMGQDE VYLKVISTSG SNSEKKLAKR VLDLISRGKH 120
WVLVTLLLSN VITNETLPIV LDRCLGGGWQ AVVSSTILIV IFGEIIPQSV CVKYGLQVGA 180
FFCPFVLVLM YLMYPVAYPI ATLLDYMLGE DHGTMYKKSG LKTLVTLHRT MGVERLTKDE 240
VTIISAVLDL KAKRVEEIMT PIENVFTMSA DTILDDKTVE KIFNSGFSRI PIFLPNEPNN 300
FIGMLLVRVL ISYDPDDCLP ISHFPLATLP ETSPNTSCLN ILNYFQEGKA HMCVVSKEPG 360
SSHGAIGVLT LEDVIEELIG EEIVDESDVF VDMHQHIMRQ QPGPLSKRHI TSYLHHLYTS 420
SHKEHKAADQ ADESSPLLSP SNSNHPSEHP QQDLNNKSWK QKSNDGYDRS NAVLSPTPQV 480
TEHGTIIPSN LASNPLNVNK SFVTIKKPAN VPKIITTHTP HSSKEPSPAP HSNDKSLSAE 540
EQQLLSDHAE LSRQAVLHTQ RSGQPTQVTT STKTTRNSPD SISIPNSGAN HGNENQNVTI 600
STSYQNTKNG IVESVITVKG VPKTIIGPAK DWDESKSEYG NENINQENSN RSDDRESSSS 660
NASLFSSIKN KFKNENANNN DRSNFTDSLS RTSNYDANGS SSTIKR 706 
Gene Ontology
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0030026; P:cellular manganese ion homeostasis; IMP:SGD.
 GO:0007005; P:mitochondrion organization; IMP:SGD. 
Interpro
 IPR000644; Cysta_beta_synth_core.
 IPR002550; DUF21. 
Pfam
 PF01595; DUF21 
SMART
  
PROSITE
 PS51371; CBS 
PRINTS