CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001424
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Latrophilin-1 
Protein Synonyms/Alias
 Calcium-independent alpha-latrotoxin receptor 1; CIRL-1 
Gene Name
 Lphn1 
Gene Synonyms/Alias
 Cirl; Cirl1; Cl1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1202MWNDTVRKQTESSFMubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis. 
Sequence Annotation
 DOMAIN 40 129 SUEL-type lectin.
 DOMAIN 139 398 Olfactomedin-like.
 DOMAIN 798 849 GPS.
 REGION 117 120 Carbohydrate binding (By similarity).
 BINDING 42 42 Carbohydrate (By similarity).
 MOD_RES 1418 1418 Phosphoserine (By similarity).
 CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
 CARBOHYD 531 531 N-linked (GlcNAc...).
 CARBOHYD 640 640 N-linked (GlcNAc...).
 CARBOHYD 741 741 N-linked (GlcNAc...).
 CARBOHYD 800 800 N-linked (GlcNAc...).
 CARBOHYD 805 805 N-linked (GlcNAc...) (Potential).
 CARBOHYD 826 826 N-linked (GlcNAc...).
 DISULFID 41 71 By similarity.
 DISULFID 50 128 By similarity.
 DISULFID 83 115 By similarity.
 DISULFID 96 102 By similarity.
 DISULFID 140 322 By similarity.
 DISULFID 480 515
 DISULFID 503 532
 DISULFID 801 832
 DISULFID 820 834  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Cell projection; Complete proteome; Direct protein sequencing; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lectin; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Synapse; Synaptosome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1515 AA 
Protein Sequence
MARLAAALWS LCVTTVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC PGSDVIMVEN 60
ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT QCVVVAGSDA FPDPCPGTYK 120
YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP TSTHESEHQS GAWCKDPLQA GDRIYVMPWI 180
PYRTDTLTEY ASWEDYVAAR HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT 240
RIKSGETVIN TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL 300
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT NANREEPVSL 360
AFPNPYQFVS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD PSAGPATSPP LSTTTTARPT 420
PLTSTASPAA TTPLRRAPLT THPVGAINQL GPDLPPATAP APSTRRPPAP NLHVSPELFC 480
EPREVRRVQW PATQQGMLVE RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV 540
AQKIKSGENA ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG 600
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM LLDVLEEGAF 660
LLADNVREPA RFLAAKQNVV LEVTVLSTEG QVQELVFPQE YASESSIQLS ANTIKQNSRN 720
GVVKVVFILY NNLGLFLSTE NATVKLAGEA GTGGPGGASL VVNSQVIAAS INKESSRVFL 780
MDPVIFTVAH LEAKNHFNAN CSFWNYSERS MLGYWSTQGC RLVESNKTHT TCACSHLTNF 840
AVLMAHREIY QGRINELLLS VITWVGIVIS LVCLAICIST FCFLRGLQTD RNTIHKNLCI 900
NLFLAELLFL VGIDKTQYEV ACPIFAGLLH YFFLAAFSWL CLEGVHLYLL LVEVFESEYS 960
RTKYYYLGGY CFPALVVGIA AAIDYRSYGT EKACWLRVDN YFIWSFIGPV SFVIVVNLVF 1020
LMVTLHKMIR SSSVLKPDSS RLDNIKSWAL GAIALLFLLG LTWAFGLLFI NKESVVMAYL 1080
FTTFNAFQGV FIFVFHCALQ KKVHKEYSKC LRHSYCCIRS PPGGAHGSLK TSAMRSNTRY 1140
YTGTQVPGQG RHIHQVSLGP RGRSALPESQ KDPGGQSGPG DPLTFGLCPS RIRRMWNDTV 1200
RKQTESSFMA GDINSTPTLN RGTMGNHLLT NPVLQPRGGT SPYNTLIAES VGFNPSSPPV 1260
FNSPGSYREP KHPLGGREAC GMDTLPLNGN FNNSYSLRSG DFPPGDGGPE PPRGRNLADA 1320
AAFEKMIISE LVHNNLRGAS GGAKGPPPEP PVPPVPGVSE DEAGGPGGAD RAEIELLYKA 1380
LEEPLLLPRA QSVLYQSDLD ESESCTAEDG ATSRPLSSPP GRDSLYASGA NLRDSPSYPD 1440
SSPEGPNEAL PPPPPAPPGP PEIYYTSRPP ALVARNPLQG YYQVRRPSHE GYLAAPSLEG 1500
PGPDGDGQMQ LVTSL 1515 
Gene Ontology
 GO:0030424; C:axon; IDA:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030426; C:growth cone; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0014069; C:postsynaptic density; IDA:RGD.
 GO:0042734; C:presynaptic membrane; IDA:UniProtKB.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0050839; F:cell adhesion molecule binding; IDA:UniProtKB.
 GO:0004930; F:G-protein coupled receptor activity; IDA:RGD.
 GO:0016524; F:latrotoxin receptor activity; IDA:RGD.
 GO:0015643; F:toxic substance binding; IPI:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IDA:UniProtKB.
 GO:0007157; P:heterophilic cell-cell adhesion; IDA:UniProtKB.
 GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
 GO:0090129; P:positive regulation of synapse maturation; IDA:UniProtKB.
 GO:0016079; P:synaptic vesicle exocytosis; TAS:RGD. 
Interpro
 IPR022624; DUF3497.
 IPR017981; GPCR_2-like.
 IPR001879; GPCR_2_extracellular_dom.
 IPR003924; GPCR_2_latrophilin.
 IPR003334; GPCR_2_latrophilin_rcpt_C.
 IPR000832; GPCR_2_secretin-like.
 IPR017983; GPCR_2_secretin-like_CS.
 IPR000203; GPS_dom.
 IPR000922; Lectin_gal-bd_dom.
 IPR003112; Olfac-like. 
Pfam
 PF00002; 7tm_2
 PF12003; DUF3497
 PF02140; Gal_Lectin
 PF01825; GPS
 PF02793; HRM
 PF02354; Latrophilin
 PF02191; OLF 
SMART
 SM00303; GPS
 SM00008; HormR
 SM00284; OLF 
PROSITE
 PS00649; G_PROTEIN_RECEP_F2_1
 PS00650; G_PROTEIN_RECEP_F2_2
 PS50227; G_PROTEIN_RECEP_F2_3
 PS50261; G_PROTEIN_RECEP_F2_4
 PS50221; GPS
 PS51132; OLF
 PS50228; SUEL_LECTIN 
PRINTS
 PR00249; GPCRSECRETIN.
 PR01444; LATROPHILIN.